Molecular structure of Tafluprost, CAS Number: 209860-87-7
Tafluprost (CAS 209860-87-7)
Alternate Names:
AFP-168
Application:
Tafluprost is an FP receptor agonist
CAS Number:
209860-87-7
Molecular Weight:
452.54
Molecular Formula:
C25H34F2O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Tafluprost is a very potent prostaglandin F (FP) receptor agonist (Ki = 0.4 nM). Tafluprost is a 2-series, 16-phenoxy analog of PGF2αwith the 15,15-difluoro substitution.
Tafluprost (CAS 209860-87-7) References
- The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. | Abramovitz, M., et al. 2000. Biochim Biophys Acta. 1483: 285-93. PMID: 10634944
- The pharmacology of bimatoprost (Lumigan). | Woodward, DF., et al. 2001. Surv Ophthalmol. 45 Suppl 4: S337-45. PMID: 11434936
- The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. | Maxey, KM., et al. 2002. Surv Ophthalmol. 47 Suppl 1: S34-40. PMID: 12204699
- New fluoroprostaglandin F(2alpha) derivatives with prostanoid FP-receptor agonistic activity as potent ocular-hypotensive agents. | Nakajima, T., et al. 2003. Biol Pharm Bull. 26: 1691-5. PMID: 14646172
- The IOP-lowering effects and mechanism of action of tafluprost in prostanoid receptor-deficient mice. | Ota, T., et al. 2007. Br J Ophthalmol. 91: 673-6. PMID: 17124244
- In vitro effects of preservative-free tafluprost and preserved latanoprost, travoprost, and bimatoprost in a conjunctival epithelial cell line. | Brasnu, E., et al. 2008. Curr Eye Res. 33: 303-12. PMID: 18398704
- Conjunctival and corneal reactions in rabbits following short- and repeated exposure to preservative-free tafluprost, commercially available latanoprost and 0.02% benzalkonium chloride. | Liang, H., et al. 2008. Br J Ophthalmol. 92: 1275-82. PMID: 18723745
- Disposition and metabolism of a novel prostanoid antiglaucoma medication, tafluprost, following ocular administration to rats. | Fukano, Y. and Kawazu, K. 2009. Drug Metab Dispos. 37: 1622-34. PMID: 19477946
- Tafluprost for glaucoma. | Papadia, M., et al. 2011. Expert Opin Pharmacother. 12: 2393-401. PMID: 21916788
- In vitro study of antiadipogenic profile of latanoprost, travoprost, bimatoprost, and tafluprost in human orbital preadiopocytes. | Choi, HY., et al. 2012. J Ocul Pharmacol Ther. 28: 146-52. PMID: 22107041
- Tafluprost: the first preservative-free prostaglandin to treat open-angle glaucoma and ocular hypertension. | Swymer, C. and Neville, MW. 2012. Ann Pharmacother. 46: 1506-10. PMID: 23092867
- An Asymmetric Suzuki-Miyaura Approach to Prostaglandins: Synthesis of Tafluprost. | Kučera, R., et al. 2020. Org Lett. 22: 2991-2994. PMID: 32216289
- Phenyl-substituted prostaglandins: potent and selective antiglaucoma agents. | Resul, B., et al. 1993. J Med Chem. 36: 243-8. PMID: 8423596
Activator of:
PGF2alphaR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tafluprost, 500 µg | sc-222336 | 500 µg | $69.00 | |||
Tafluprost, 1 mg | sc-222336A | 1 mg | $166.00 |