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RO1138452 (CAS 221529-58-4)

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Synonym:4,​5-dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-1H-imadazol-2-amine
Application:An IP receptor antagonist
CAS Number:221529-58-4
Molecular Weight:309.4
Molecular Formula:C19H23N3O
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
RO1138452 sc-222261 1 mg $102
RO1138452 sc-222261A 5 mg $462
Description
RO1138452 is one of the more potent high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. RO1138452 antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, RO1138452 inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 1.5 nM. At levels between 2-20 mg/kg in rats, RO1138452 shows significant analgesic activity in standard antinociceptive assays.
Technical Information
Physical State:Solid
Storage:Store at -20° C
Safety and Reference Information
SMILES:CC(C)Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1 Clark, R.D., Jahangir, A., Severance, D., et al. Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists. Bioorg Medicinal Chem Letters 14 1053-1056 (2004).
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