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(R)-Equol (CAS 221054-79-1)

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Application:A non-steroidal estrogen produced from the metabolism of daidzein
CAS Number:221054-79-1
Molecular Weight:242.3
Molecular Formula:C15H14O3
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
(R)-Equol sc-222235 1 mg $26
(R)-Equol sc-222235A 5 mg $118
Description
A non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora. It is a chiral molecule that exists in two enantiomeric forms. In contrast to the estrogen receptor selectivity of (S)-equol , (R)-equol is a weaker ER agonist that binds to ERα and ERβ with Kι values of 27.4 and 15.4 nM, respectively. The (R)-enantiomer demonstrates higher ER agonist activity at ERα compared to ERβ.
Technical Information
Physical State:Solid
Solubility:Soluble in ethanol (~20 mg/ml), DMSO (~20 mg/ml), DMF (~10 mg/ml), and ethanol : PBS (1:10, pH 7.2) (~0.1 mg/ml).
Storage:Store at -20° C
Melting Point:155.69 °C (Predicted)
Boiling Point:441.72 °C at 760 mmHg (Predicted)
Density:1.29 g/cm3 (Predicted)
Refractive Index:n20D 1.65 (Predicted)
Safety and Reference Information
MDL Number:MFCD09025608
SMILES:C1C(COC2=C1C=CC(=C2)O)C3=CC=C(C=C3)O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1 Setchell, K.D.R., Clerici, C., Lephart, E.D., et al. S-equol, a potent ligand for estrogen receptor b, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr 81 1072-1079 (2005). 2 Muthyala, R.S., Ju, Y.H., Sheng, S., et al. Equol, a natural estrogenic metabolite from soy isoflavones: Convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorg Med Chem 12 1559-1567 (2004).
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