Pravastatin (CAS 81093-37-0)
See product citations (1)
QUICK LINKS
Pravastatin is a competitive inhibitor of HMG-CoA reductase, an enzyme involved in the production of cholesterol in the liver. By inhibiting this enzyme, pravastatin reduces the production of cholesterol, leading to a decrease in the levels of LDL cholesterol in the blood. Pravastatin functions by binding to the active site of HMG-CoA reductase, preventing the conversion of HMG-CoA to mevalonate, a key step in cholesterol biosynthesis. This inhibition ultimately leads to an upregulation of LDL receptors on the surface of hepatocytes, increasing the uptake and clearance of LDL cholesterol from the bloodstream. Pravastatin may have anti-inflammatory and antioxidant effects, which may contribute to its impact on lipid metabolism. At the molecular level, pravastatin′s mechanism of action involves interfering with the mevalonate pathway, ultimately leading to a reduction in cholesterol synthesis.
Pravastatin (CAS 81093-37-0) References
- Pravastatin. A pharmacoeconomic review of its use in primary and secondary prevention of coronary heart disease. | Coukell, AJ. and Wilde, MI. 1998. Pharmacoeconomics. 14: 217-36. PMID: 10186462
- Pravastatin: a review of its use in elderly patients. | Bang, LM. and Goa, KL. 2003. Drugs Aging. 20: 1061-82. PMID: 14651445
- Pravastatin-induced lichenoid drug eruption. | Pua, VS., et al. 2006. Australas J Dermatol. 47: 57-9. PMID: 16405486
- Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. | McTavish, D. and Sorkin, EM. 1991. Drugs. 42: 65-89. PMID: 1718686
- Pravastatin: an evidence-based statin? | del Sol, AI. and Nanayakkara, PW. 2008. Expert Opin Drug Metab Toxicol. 4: 821-5. PMID: 18611121
- Pharmacogenomic importance of pravastatin. | Peters, B. and Maitland-van der Zee, AH. 2008. Pharmacogenomics. 9: 1207-10. PMID: 18781848
- Pravastatin sodium, a new HMG-CoA reductase inhibitor. | Raasch, RH. 1991. DICP. 25: 388-94. PMID: 1926908
- Pravastatin to treat and prevent preeclampsia. Preclinical and clinical studies. | Girardi, G. 2017. J Reprod Immunol. 124: 15-20. PMID: 29028516
- Pravastatin for Preventing and Treating Preeclampsia: A Systematic Review. | Esteve-Valverde, E., et al. 2018. Obstet Gynecol Surv. 73: 40-55. PMID: 29368790
- Statin therapy increases lipoprotein(a) levels. | Tsimikas, S., et al. 2020. Eur Heart J. 41: 2275-2284. PMID: 31111151
- Pravastatin for preeclampsia: From animal to human. | Kumasawa, K., et al. 2020. J Obstet Gynaecol Res. 46: 1255-1262. PMID: 32485787
- Pravastatin-Induced Acute Pancreatitis: A Case Report and Literature Review. | Tarar, ZI., et al. 2021. J Investig Med High Impact Case Rep. 9: 23247096211028386. PMID: 34180257
- Aspirin and Pravastatin for Preeclampsia Prevention in High-Risk Pregnancy. | Eid, J., et al. 2023. Obstet Gynecol Clin North Am. 50: 79-88. PMID: 36822711
- Pravastatin. A reappraisal of its pharmacological properties and clinical effectiveness in the management of coronary heart disease. | Haria, M. and McTavish, D. 1997. Drugs. 53: 299-336. PMID: 9028747
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pravastatin, 50 mg | sc-222188 | 50 mg | $400.00 |