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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the C-terminus of EDG-3 of human origin
- recommended for detection of EDG-3 of human and, to a lesser extent, mouse and rat origin by WB, IF and ELISA
- blocking peptide, sc-22211 P
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Ordering Information
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
EDG3 |
1903 |
9q22.1 |
NM_005226 |
Q99500
|
601965 |
| Mouse |
S1pr3 |
13610 |
13 A5 |
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Q9Z0U9
|
N/A |
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EDG-3 Background Information
The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. EDG-6, which is expressed in lymphoid and hematopoietic tissues and in lung, signals through G(i/o) proteins, which activate growth related pathways. |
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EDG-3 (G-17)
Click on image to enlarge
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EDG-3 (G-17): sc-22211. Immunofluorescence staining of methanol-fixed Hep G2 cells showing membrane localization.
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