santa cruz biotechnology, inc.
SCBT Logo

Welcome!        Items in Cart     Quick Order
home » Membrane Receptors » EDG-3 Antibody / EDG-3 Antibodies » EDG-3 (H-15): sc-22210

EDG-3 (H-15) Antibody: sc-22210

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping within an extracellular domain of EDG-3 of human origin
  • recommended for detection of EDG-3 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-22210 P
 
Additional EDG-3 Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human EDG3 1903 9q22.1 NM_005226 Q99500
 601965
Mouse S1pr3 13610 13 A5 Q9Z0U9
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
EDG-3 (H-15) sc-22210 200 µg/ml $279
EDG-3 (H-15) P sc-22210 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
EDG-3 siRNA (h) sc-35261 10 µM $258
EDG-3 siRNA (m) sc-35262 10 µM $258
EDG-3 (h)-PR sc-35261-PR 10 µM $23
EDG-3 (m)-PR sc-35262-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
EDG-3 shRNA Plasmid (h) sc-35261-SH 20 µg $520
EDG-3 shRNA Plasmid (m) sc-35262-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
EDG-3 shRNA (h) Lentiviral Particles sc-35261-V 200 µl $625
EDG-3 shRNA (m) Lentiviral Particles sc-35262-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
mouse liver extract sc-2256 500 µg/200 µl $104
Hep G2 Cell Lysate sc-2227 500 µg/200 µl $104
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104

EDG-3 Background Information
The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. EDG-6, which is expressed in lymphoid and hematopoietic tissues and in lung, signals through G(i/o) proteins, which activate growth related pathways.

EDG-3 (H-15)
Click on image to enlarge
sc-22210
EDG-3 (H-15): sc-22210. Immunofluorescence staining of methanol-fixed Hep G2 cells showing membrane localization.
Download
Datasheets
Get Adobe Acrobat Reader