Molecular structure of N-Acetyl-D-galactosamine, CAS Number: 1811-31-0
N-Acetyl-D-galactosamine (CAS 1811-31-0)
Alternate Names:
2-Acetamido-2-deoxy-D-galactose; D-GalNAc; N-Acetylchondrosamine
Application:
N-Acetyl-D-galactosamine is an aminosugar derivative
CAS Number:
1811-31-0
Purity:
≥97%
Molecular Weight:
221.21
Molecular Formula:
C8H15NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-Acetyl-D-galactosamine is an aminosugar derivative that acts as the initial O-linked sugar in serine and threonine residues in protein glycosylations. N-Acetyl-D-galactosamine is a type of aldohexose known as 2-acetamido-2-deoxygalactose, where the hydroxyl group at position 2 is substituted by an N-acetyl group. It plays a vital role in the structure of N- and O-linked glycoproteins, glycolipids, gangliosides, blood groups, glycosaminoglycans, and human milk oligosaccharides.
N-Acetyl-D-galactosamine (CAS 1811-31-0) References
- Incorporation of N-acetylgalactosamine into consecutive threonine residues in MUC2 tandem repeat by recombinant human N-acetyl-D-galactosamine transferase-T1, T2 and T3. | Iida, S., et al. 1999. FEBS Lett. 449: 230-4. PMID: 10338138
- Synthesis of N-acetyl-D-galactosamine and folic acid conjugated ribozymes. | Matulic-Adamic, J., et al. 2002. Bioconjug Chem. 13: 1071-8. PMID: 12236789
- Purification and characterization of an N-acetyl-D-galactosamine-specific lectin from seeds of chickpea (Cicer arietinum L.). | Qureshi, IA., et al. 2006. Phytochem Anal. 17: 350-6. PMID: 17019937
- An efficient conversion of N-acetyl-D-glucosamine to N-acetyl-D-galactosamine and derivatives. | Feng, J. and Ling, CC. 2010. Carbohydr Res. 345: 2450-7. PMID: 20943215
- Transport of N-acetyl-D-glucosamine and N-acetyl-D-galactosamine by rat liver lysosomes. | Jonas, AJ., et al. 1989. J Biol Chem. 264: 4953-6. PMID: 2784441
- N-Acetyl-d-galactosamine prevents soya bean agglutinin-induced intestinal barrier dysfunction in intestinal porcine epithelial cells. | Zhao, B., et al. 2019. J Anim Physiol Anim Nutr (Berl). 103: 1198-1206. PMID: 30934149
- Cellular uptake of N-acetyl-d-galactosamine-, N-acetyl-d-glucosamine- and d-mannose-containing fluorescent glycoconjugates investigated by liver intravital microscopy. | Maklakova, SY., et al. 2020. Carbohydr Res. 489: 107928. PMID: 32062176
- LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation. | Ahn, G., et al. 2021. Nat Chem Biol. 17: 937-946. PMID: 33767387
- A N-acetyl-D-galactosamine-binding lectin from Amaranthus gangeticus seeds inhibits biofilm formation and Ehrlich ascites carcinoma cell growth in vivo in mice. | Hasan, I., et al. 2021. Int J Biol Macromol. 181: 928-936. PMID: 33878355
- N-Acetyl Galactosamine Targeting: Paving the Way for Clinical Application of Nucleotide Medicines in Cardiovascular Diseases. | Biessen, EAL. and Van Berkel, TJC. 2021. Arterioscler Thromb Vasc Biol. 41: 2855-2865. PMID: 34645280
- Structural differences between two lectins from Cytisus scoparius, both specific for D-galactose and N-acetyl-D-galactosamine. | Young, NM., et al. 1984. Biochem J. 222: 41-8. PMID: 6477513
- N-acetyl-D-galactosamine inhibits TNF-alpha gene expression induced in mouse peritoneal macrophages by fimbriae of Porphyromonas (Bacteroides) gingivalis, an oral anaerobe. | Murakami, Y., et al. 1993. Biochem Biophys Res Commun. 192: 826-32. PMID: 8097914
- Two N-acetyl-D-galactosamine-specific lectins from Phaeolepiota aurea. | Kawagishi, H., et al. 1996. Phytochemistry. 41: 1013-6. PMID: 8728711
Inhibitor of:
β-Galactosidase, ASGPR1, ASGPR2, ficolin B, GALK2, GalNAc-TL1, L-ficolin, and Mgl2.Activator of:
ABO Blood Group Antigens, Blood Group Lewis x, C1GALT1, CHSY3, CLEC-18A, Galactose Mutarotase, GalNAc-T14, GalNAc-T17, GalNAc-T2, GalNAc-TL4, GCNT2, GM2/GD2 Synthase, Lewis Blood Group Antigen, MBL-A, MNS Blood Group Antigens, NAGA, Sialyl Lewis a, and Thomsen-Friedenreich.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Acetyl-D-galactosamine, 10 mg | sc-221979 | 10 mg | $50.00 | |||
N-Acetyl-D-galactosamine, 100 mg | sc-221979A | 100 mg | $75.00 | |||
N-Acetyl-D-galactosamine, 1 g | sc-221979C | 1 g | $262.00 | |||
N-Acetyl-D-galactosamine, 5 g | sc-221979B | 5 g | $1020.00 | |||
N-Acetyl-D-galactosamine, 50 g | sc-221979D | 50 g | $1300.00 |