iso-Ins(1,4,5)P3/PM (caged)
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iso-Ins(1,4,5)P3/PM (caged) is a chemically modified form of inositol trisphosphate (IP3), a crucial second messenger involved in intracellular calcium signaling. The "caged" form refers to a modification that renders the molecule inactive until it is activated by a specific external stimulus, typically light. Upon activation, the cage is removed, releasing the active compound. This chemical modification enables precise temporal and spatial control over the activation of IP3 signaling pathways in cellular and physiological contexts. Researchers utilize iso-Ins(1,4,5)P3/PM (caged) as a powerful tool to investigate the dynamics and specificity of IP3-mediated signaling events with high spatiotemporal resolution. By controlling the timing and location of IP3 release using light or other triggers, scientists can dissect the complex mechanisms underlying various cellular processes, including neurotransmission, muscle contraction, and hormone secretion. Additionally, iso-Ins(1,4,5)P3/PM (caged) allows for the manipulation of specific cellular signaling pathways in a non-invasive manner, facilitating the study of IP3-dependent processes in live cells and organisms. Furthermore, this compound serves as a valuable tool for elucidating the roles of IP3 signaling in diverse physiological and pathological conditions, including neuronal development, synaptic plasticity, and cancer progression. Overall, iso-Ins(1,4,5)P3/PM (caged) represents an essential research tool for unraveling the complexities of IP3-mediated signaling pathways and their implications in cellular physiology and disease.
iso-Ins(1,4,5)P3/PM (caged) References
- Co-incident signalling between mu-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: lack of evidence for Ins(1,4,5)P3 receptor sensitization. | Samways, DS., et al. 2003. Biochem J. 375: 713-20. PMID: 12880387
- Phosphorylation of type-1 inositol 1,4,5-trisphosphate receptors by cyclic nucleotide-dependent protein kinases: a mutational analysis of the functionally important sites in the S2+ and S2- splice variants. | Wagner, LE., et al. 2003. J Biol Chem. 278: 45811-7. PMID: 12939273
- Abnormal spatial diffusion of Ca2+ in F508del-CFTR airway epithelial cells. | Antigny, F., et al. 2008. Respir Res. 9: 70. PMID: 18973672
- The contribution of inositol 1,4,5-trisphosphate and ryanodine receptors to agonist-induced Ca(2+) signaling of airway smooth muscle cells. | Bai, Y., et al. 2009. Am J Physiol Lung Cell Mol Physiol. 297: L347-61. PMID: 19465516
- Critical role of ATP-induced ATP release for Ca2+ signaling in nonsensory cell networks of the developing cochlea. | Ceriani, F., et al. 2016. Proc Natl Acad Sci U S A. 113: E7194-E7201. PMID: 27807138
- On the dynamical structure of calcium oscillations. | Sneyd, J., et al. 2017. Proc Natl Acad Sci U S A. 114: 1456-1461. PMID: 28154146
- Intercellular Calcium Signaling Induced by ATP Potentiates Macrophage Phagocytosis. | Zumerle, S., et al. 2019. Cell Rep. 27: 1-10.e4. PMID: 30943393
- Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression. | Li, W., et al. 1998. Nature. 392: 936-41. PMID: 9582076
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
iso-Ins(1,4,5)P3/PM (caged), 20 µg | sc-221767 | 20 µg | $342.00 | |||
iso-Ins(1,4,5)P3/PM (caged), 100 µg | sc-221767A | 100 µg | $940.00 |