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Indirubin-3'-monoxime-5-sulphonic Acid (CAS 331467-05-1)

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Application:An inhibitor of GSK-3β, Cdk1 and Cdk5.
CAS Number:331467-05-1
Purity:100%
Molecular Weight:357.3
Molecular Formula:C16H11N3O5S
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Indirubin-3'-monoxime-5-sulphonic Acid sc-221753 1 mg $238
Description
Indirubin-3'-monoxime-5-sulphonic Acid is a potent, reversible, and selective inhibitor of Cdk1 (IC50 = 5 nM) and Cdk5 (IC50 = 7 nM) and GSK-3 beta (GSK-3β; IC50 = 80 nM). The inhibition is competitive with respect to ATP.
Technical Information
Physical State:Solid
Solubility:Soluble in DMSO.
Storage:Store at -20° C
Density:1.77 g/cm3 (Predicted)
Refractive Index:n20D 1.81 (Predicted)
IC50:Cdk1: IC50 = 5 nM; Cdk5: IC50 = 7 nM; glycogen synthase kinase-3β: IC50 = 80 nM; tyrosine-protein kinase receptor FLT3: IC50 = 9 nM (human)
pK Values:pKa: -0.57 (Predicted)
Safety and Reference Information
PubChem CID:10474839
SMILES:C1=CC=C2C(=C1)C(=C(N2)C3=C4C=C(C=CC4=NC3=O)S(=O)(=O)O)NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Leclerc, S., et al. 2001. J. Biol. Chem. 276: 251-260. PMID: 11013232
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