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Glucocorticoid Receptor Modulator, CpdA (CAS 14593-25-0)

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Synonym:2-((4-Acetoxyphenyl)-2-chloro-N-methyl)ethylammonium chloride
Application:A cell-permeable aziridine precursor
CAS Number:14593-25-0
Molecular Weight:264.15
Molecular Formula:C11H14ClNO2•HCl
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Glucocorticoid Receptor Modulator, CpdA sc-221677 25 mg $124
Glucocorticoid receptor modulator, CpdA, is a cell-permeable aziridine precursor that acts as a non-steroidal, GR (glucocorticoid receptor)-activating ligand with a binding affinity that is 4-fold higher than that of dexamethasone (sc-29059). Glucocorticoid Receptor Modulator, CpdA, induces GR nuclear translocation and selectively activates GR-mediated transrepression of the NF-κB-dependent production of pro-inflammatory cytokines. Unlike DEX, CpdA exhibits no effect on GRE- (glucocorticoid response element) driven gene expression.
Technical Information
Physical State:Solid
Solubility:Soluble in ethanol (5 mg/ml), DMSO (10 mg/ml), and water (1 mg/ml).
Storage:Store at -80° C
Melting Point:184-191 °C
Boiling Point:324.6 °C at 760 mmHg (Predicted)
Refractive Index:n20D ~1.52 (Predicted)
Safety and Reference Information
PubChem CID:9838147
MDL Number:MFCD16883076
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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