Welcome to Santa Cruz Biotechnology!

CVT-313 (CAS 199986-75-9)

  See 1 review  |  Add your review

Application:An inhibitor of Cdk2
CAS Number:199986-75-9
Molecular Weight:400.5
Molecular Formula:C20H28N6O3
Refer to Certificate of Analysis for lot specific data (including water content).
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
CVT-313 sc-221445 1 mg $69
CVT-313 sc-221445A 5 mg $268
CVT-313 is a cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). It inhibits other kinases only at much higher concentrations.
Technical Information
Physical State:Solid
Solubility:Soluble in DMSO (10 mg/ml), DMF, and 100% ethanol.
Storage:Store at -20° C
Melting Point:268.02° C (Predicted)
Refractive Index:n20D 1.63 (Predicted)
IC50:CDK2/cyclin A: IC50 = 500 nM; CDK2/cyclin E: IC50 = 500 nM; CDK1/cyclin B: IC50 = 4.2 µM; CDK4/cyclin D1: IC50 = 215 µM; MAPK: IC50 >1.25 mM; Induce tumor cells growth arrest: IC50 = 1.25-20 µM; Cyclin-dependent kinase 1: IC50 = 330 µM (human); PKA: IC50 >1.25 mM; PKC: IC50 >1.25 mM
pK Values:pKa: 13.95 (Predicted), pKb: 6.85 (Predicted)
Safety and Reference Information
PubChem CID:6918386
MDL Number:MFCD06411412
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

CVT-313 Product Reviews

1 total reviews.
Add your review!
Loading Reviews.

1. CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation: E.E. Brooks, et al.; J. Biol. Chem. 272, 29207 (1997) 2. Histone H1 phosphorylation by Cdk2 selectively modulates mouse mammary tumor virus transcription through chromatin remodeling: R.N. Bhattacharjee, et al.; Mol. Cell. Biol. 21, 5417 (2001)
CVT-313 (CAS 199986-75-9) Product Citations
See how others have used CVT-313 (CAS 199986-75-9).

4 total citations
Loading citations.
Certificate of Analysis

Catalog Number

Lot Number

Related Product Categories