Welcome to Santa Cruz Biotechnology!
SCBT Home
Home » Chemicals » Phosphatases and Phosphatase Activators and Inhibitors » bpV(phen): sc-221378

bpV(phen) (CAS 42494-73-5)

(Based on popularity)

Application:A peroxovanadium insulin mimetic compound
CAS Number:42494-73-5
Purity:≥98%
Molecular Weight:404.3
Molecular Formula:K[VO(O2)2C12H8N2] . 3H2O
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
bpV(phen) sc-221378 5 mg $60
bpV(phen) sc-221378A 25 mg $214
Description
bpV(phen), or potassium bisperoxo (1,10-phenanthroline) oxovanadate, is a peroxovanadium (pV) small molecule with insulin-mimetic properties. bpV(phen) and other pV compounds were demonstrated to activate insulin receptor kinase in hepatocytes and to inhibit the dephosphorylation of autophosphorylated insulin receptors, correlated to significant decreases of circulating insulin and plasma glucose levels. Inhibition of an endosomally-located protein phosphotyrosine phosphatase by bpV(phen) produces this blockade of insulin receptor dephosphorylation. bpV(phen) is also described to activate a signal pathway which abrogates dexamethasone/glucagon-induced increase of IGFBP-1 (insulin-like growth factor binding protein-1) mRNA, and this effect is suggested to be mediated through MAP kinase activity stimulated by bpV(phen) inhibition of tyrosine phosphatases involved in MAP kinase regulation.
Technical Information
Appearance:Yellow to orange powder
Physical State:Solid
Solubility:Soluble in water (10 mM), and DMSO.
Storage:Store at -20° C
IC50:PTEN: IC50 = 38 nM
Safety and Reference Information
SMILES:[K+].O=[V].OO.OO.n1c3c(ccc1)ccc2cccnc23
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Posner, B.I., et al. 1994. J. Biol. Chem. 269: 4596-4604. PMID: 8308031
2. Bevan, A.P., et al. 1995. Am. J. Physiol. 268: E60-E66. PMID: 7840184
3. Yale, J.F., et al. 1995. Diabetes. 44: 1274-1279. PMID: 7589823
4. Drake, P.G., et al. 1996. Endocrinology. 137: 4960-4968. PMID: 8895369
5. Band, C.J., et al. 1997. J. Biol. Chem. 272: 138-145. PMID: 8995239
bpV(phen) (CAS 42494-73-5) Product Citations
See how others have used bpV(phen) (CAS 42494-73-5).


1 total citations
Loading citations.
SDS
Related Product Categories