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phospholamban Antibody (L-15): sc-21923

 |  Datasheet

(Based on data analysis)

  • phospholamban Antibody (L-15) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping at the N-terminus of phospholamban of human origin
  • recommended for detection of phospholamban of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-21923 P
  • See 1 citations for phospholamban Antibody (L-15)
 

See additional Phospholamban Antibodies.

Ordering InformationProduct CitationsGene Info
Recommended Support Products:
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WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
phospholamban Antibody (L-15) sc-21923 200 µg/ml $279
phospholamban (L-15) P sc-21923 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
phospholamban siRNA (h) sc-39143 10 µM $258
phospholamban siRNA (m) sc-39144 10 µM $258
phospholamban (h)-PR sc-39143-PR 10 µM, 20 µl $23
phospholamban (m)-PR sc-39144-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
phospholamban shRNA Plasmid (h) sc-39143-SH 20 µg $520
phospholamban shRNA Plasmid (m) sc-39144-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
phospholamban shRNA (h) Lentiviral Particles sc-39143-V 200 µl $625
phospholamban shRNA (m) Lentiviral Particles sc-39144-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
rat heart extract sc-2393 500 µg/200 µl $104
mouse heart extract sc-2254 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PLN 5350 6q22.31 NM_002667 P26678
 609909
Mouse Pln 18821 10 B3 P61014
 N/A
 

The Sarco(endo)plasmic-reticulum (SER) regulatory protein, Phospholamban (PLB), is a small, plasma membrane-associated phospho-protein found in the SER of cardiac, smooth and slow-twitch muscle. Believed to assemble into a pentamer, PLB regulates cardiac contractility and Ca2+ affinity for cardiac SER Ca2+ ATPase (SERCA2a). Non-phosphorylated PLB associates with SERCA2a, and inhibits Ca2+ reuptake into the SER. PLB activation occurs when key Serine/Threonine residues in PLB (Ser-10, Ser-16, Thr-17) are phosphorylated by numerous effectors, which include PKC, PKA, PKG, and CaM kinase. Phosphorylation of PLB causes dissociation from SERCA2a and a subsequent increase in the rate of Ca2+ reuptake into the SER, which accelerates ventricular relaxation.

phospholamban Antibody (L-15) Product Citations
See how others have used phospholamban Antibody (L-15) and or phospholamban Antibody (L-15) conjugates.


1 total citations
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phospholamban Antibody (L-15) Data
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sc-21923
phospholamban (L-15): sc-21923. Western blot analysis of phospholamban expression in rat heart (A) and mouse heart (B) tissue extracts.
sc-21923
Western blot analysis of phospholamban phosphorylation in untreated (A,C) and lambda protein phosphatase (sc-200312A) treated (B,D) mouse heart tissue extract. Antibodies tested include p-phospholamban (Ser 16)-R: sc-12963-R (A,B) and phospholamban (L-15): sc-21923 (C,D).
sc-21923
Western blot analysis of phospholamban phosphorylation in untreated (A,C) and lambda protein phosphatase (sc-200312A) treated (B,D) mouse heart tissue extract. Antibodies tested include p-phospholamban (Thr 17)-R: sc-17024-R (A,B) and phospholamban (L-15): sc-21923 (C,D).
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