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home » Kinases and Phosphatases » PAK Antibody / PAK Antibodies » p-αPAK (Thr 423)-R: sc-21903-R

p-αPAK (Thr 423)-R Antibody: sc-21903-R

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to phosphorylated Thr 423 of αPAK of mouse origin
  • recommended for detection of Thr 423 phosphorylated αPAK of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-21903 P
 
Additional PAK Antibodies ...
 
Ordering Information
Recommended Support Products:
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WB   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
p-αPAK (Thr 423) P sc-21903 P
(peptide)
 100 µg/0.5 ml $61
p-αPAK (Thr 423)-R sc-21903-R 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
αPAK siRNA (h) sc-29700 10 µM $258
αPAK siRNA (m) sc-29701 10 µM $258
αPAK (h)-PR sc-29700-PR 10 µM $23
αPAK (m)-PR sc-29701-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
αPAK shRNA Plasmid (h) sc-29700-SH 20 µg $520
αPAK shRNA Plasmid (m) sc-29701-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
αPAK shRNA (h) Lentiviral Particles sc-29700-V 200 µl $625
αPAK shRNA (m) Lentiviral Particles sc-29701-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
SK-N-SH Cell Lysate sc-2410 500 µg/200 µl $104

αPAK Background Information
p21-activated kinases (PAK) are serine/threonine kinases that link Rho GTPases to cytoskeletal reorganization and nuclear signaling. Three common isoforms are PAK1, PAK2, and PAK3 (also known as åPAK p68, ∫PAK p65 and ©PAK p62, respectively). å, ∫ and ©PAK isoforms associate with Rac 1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity and mediating their autophosphorylation. ©PAK can undergo phosphorylation on Ser-19, Ser-141 and Thr-402, and phosphorylation of Ser-141 and Thr-402 correlates with ©PAK activation. Autophosphorylation of åPAK Thr-423 (Thr-402 for ∫PAK and Thr-421 for ©PAK) is catalyzed by Cdc42 and is required for kinase activation of PAK. Once phosphorylated and their affinity for Rac/Cdc42 reduced, PAK isoforms disassociate from the complex to seek downstream substrates. One such substrate is MEK kinase, an upstream effector of MEK4 which is involved in the JNK signaling pathway.