p-Cofilin (mSer 3)-R Antibody: sc-21867-R

cofilin Background Information
LIM-kinase 1 (LIMK-1) is a serine/threonine kinase containing LIM and PDZ domains. LIMK1 phosphorylates cofilin at Serine 3 both in vitro and in vivo. Cofilin is an actin-depolymerizing factor and regulates actin cytoskeletal reorganization. Phosphorylation of cofilin on serine 3 is known to block these activities. Phosphorylation of ADF/cofilin proteins by LIMK1 or other enzymes will tend to stabilize actin filaments by inhibiting the ability of these proteins to sever and depolymerize older actin filaments that have hydrolyzed their bound ATP and dissociated the phosphate. The rapid turnover of actin filaments and the tertiary meshwork formation are regulated by a variety of actin-binding proteins. Cofilin, therefore, is a terminal effector of signaling cascades that evokes actin cytoskeletal rearrangement.