Isoimperatorin (CAS 482-45-1)
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Isoimperatorin exhibits anti-inflammatory properties and impacts proliferation. Extensive research has explored its ability to influence the expression of specific genes associated with inflammatory and metabolic pathways. Additionally, it has demonstrated potential interactions with proteins involved in cell growth and survival regulation. In bone marrow-derived mast cells, isoimperatorin has shown inhibitory effects on COX-1 and COX-2-dependent phases of prostaglandin D2 generation, with IC50 values of 24 μM and 10.7 μM, respectively. It has also exhibited inhibitory activity on leukotriene D4 production, suggesting 5-lipoxygenase inhibition. Notably, it displayed chemopreventive effects against aflatoxin B-1 on H4IIE cells by enhancing GSTα activity. Moreover, isoimperatorin completely eliminated 3-methylchoranthrene-inducible CYP1A activity at 2 μM. Although the exact mechanism of action for isoimperatorin remains incompletely understood, it is postulated to modulate the expression of specific genes involved in inflammatory and metabolic pathways. Furthermore, it is believed to interact with certain proteins that play a role in regulating cell growth and survival.
Isoimperatorin (CAS 482-45-1) References
- Potent protective effect of isoimperatorin against aflatoxin B1-inducible cytotoxicity in H4IIE cells: bifunctional effects on glutathione S-transferase and CYP1A. | Pokharel, YR., et al. 2006. Carcinogenesis. 27: 2483-90. PMID: 16829687
- The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | Moon, TC., et al. 2008. Arch Pharm Res. 31: 210-5. PMID: 18365692
- A new polymorph of isoimperatorin. | Fu, J., et al. 2018. Pharm Dev Technol. 23: 849-856. PMID: 27808578
- Isoimperatorin induces apoptosis of the SGC-7901 human gastric cancer cell line via the mitochondria-mediated pathway. | Tong, K., et al. 2017. Oncol Lett. 13: 518-524. PMID: 28123591
- Isoimperatorin enhances 3T3-L1 preadipocyte differentiation by regulating PPARγ and C/EBPα through the Akt signaling pathway. | Jiang, T., et al. 2019. Exp Ther Med. 18: 2160-2166. PMID: 31452707
- Isoimperatorin Induces Apoptosis of Nasopharyngeal Carcinoma Cells via the MAPK/ERK1/2 Signaling Pathway. | Liu, J., et al. 2020. Evid Based Complement Alternat Med. 2020: 2138186. PMID: 32215033
- Isoimperatorin (ISO) reduces melanin content in keratinocytes via miR-3619/CSTB and miR-3619/CSTD axes. | Zeng, B., et al. 2020. Biosci Biotechnol Biochem. 84: 1436-1443. PMID: 32299303
- Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway. | Hassanein, EHM., et al. 2020. Oxid Med Cell Longev. 2020: 1675957. PMID: 32377290
- Isoimperatorin reduces the effective dose of dexamethasone in a murine model of asthma by inhibiting mast cell activation. | Wang, J., et al. 2020. Phytother Res. 34: 2985-2997. PMID: 32491281
- Antiviral Activity of Isoimperatorin Against Influenza A Virus in vitro and its Inhibition of Neuraminidase. | Lai, Y., et al. 2021. Front Pharmacol. 12: 657826. PMID: 33927632
- An Efficient Ionic Liquid-Mediated Extraction and Enrichment of Isoimperatorin from Ostericum koreanum (Max.) Kitagawa. | Kiyonga, AN., et al. 2021. Molecules. 26: PMID: 34770966
- Isoimperatorin down-regulates epithelial mesenchymal transition through modulating NF-κB signaling and CXCR4 expression in colorectal and hepatocellular carcinoma cells. | Kim, NY., et al. 2022. Cell Signal. 99: 110433. PMID: 35934221
- Isoimperatorin alleviates lipopolysaccharide-induced periodontitis by downregulating ERK1/2 and NF-κB pathways. | Fan, L., et al. 2023. Open Life Sci. 18: 20220541. PMID: 36742455
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isoimperatorin, 10 mg | sc-218607 | 10 mg | $301.00 |