p-DAPK2 (Ser 318)-R Antibody: sc-21809-R

DAPK2 Background Information
Death-associated protein kinase 2 (DAPK2), also designated death-associated protein kinase-related protein-1 (DRP-1), is a calcium/calmodulin-regulated serine/threonine kinase that binds to calmodulin, undergoes autophosphoryl-ation in response to an increase in cellular calcium concentration, and phosphorylates myosin light chain (MLC) as an exogenous substrate. DAPK2 is a nuclear protein that is highly expressed in placenta, lung, pancreas and in lower levels in heart, brain, liver, skeletal muscle and kidney. DAPK2 belongs to the DAP kinase family and contains a short extra-catalytic tail that is required for homodimerization. The catalytic activity of DAPK2 is crucial in linking the cytoplasmic calcium level to apoptotic execution. The regulatory mechanism which controls its pro-apoptotic function is a single autophosphorylation event at Ser 308 (also designated Ser 318) within the Calmodulin regulatory domain. A negative charge at this site reduces both the binding to Calmodulin and the formation of DAPK-1 homodimers .