MRG1 (JA22) Antibody: sc-21795

MRG1 Background Information
MRG1 (MSG1-related gene 1) is a primary response gene that shares substantial sequence similarity to the carboxy-terminal region of MSG1 (melanocyte-specific gene-1). Both MRG1 and MSG1 contain two conserved domains designated CR1 and CR2, the latter of which is required for transcriptional activation, and they appear to represent a unique family of transcription factors. MRG1 expression is induced by cytokines, including IL-1a, IL-9, and GM-CSF, as well as by serum growth factors, and it is regulated by the JAK/ Stat pathway. Overexpression of MRG1 induces anchorage-independent growth in soft agar, loss of cell contact inhibition and tumor formation in nude mice, suggesting that MRG1 is a transforming gene with oncogenic properties. A splice variant of MRG1, designated p35srj, is ubiquitously expressed and interacts with the p300-CH1 domain of p300/CBP, where it inhibits the interaction of p300/CBP with hypoxia-inducible factor-1a (HIF-1a) to prevent HIF-1 transactivation.