DDR1 Antibody (48B3): sc-21790

DDR1 (48B3) is a mouse monoclonal IgM kappa antibody that detects DDR1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP) and flow cytometry (FCM). Anti-DDR1 antibody (48B3) is available in both conjugated and non-conjugated forms. The majority of receptor tyrosine kinases can be categorized into distinct families based on their extracellular domain structure. Only a limited number of ligands for the receptors have been described, and while most identified ligands are soluble factors, an increasing number of receptors bind to cell-surface molecules. Discoidin domain receptor 1 (DDR1), previously identified as Cak, for cell adhesion kinase (and also designated MCK-10, EDDR1, NEP, Ptk-3, RTK6, trk E or NTRK4) and discoidin domain receptor 2 (DDR2) comprise a new family of receptor tyrosine kinases involved in cell-cell interactions. Both DDR1 and DDR2 are activated by collagen. Evidence suggests that a docking site for the Shc phosphotyrosine binding domain is phosphorylated in response to DDR1 activation by collagen, whereas DDR2 activation by collagen results in upregulation of matrix metalloproteinase-1 expression.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DDR1 Antibody (48B3) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-DDR1 Antibody (48B3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DDR1 Antibody (48B3) Specifications

Alternate Product Name: Discoidin Domain Receptor 1 (DDR1)

Product Clone Name: 48B3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: DDR1

Epitope Species: human

Product Reactivity/Detection: DDR1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for DDR1 Antibody (48B3): AC: Agarose, FITC: Fluoroscein, PE: Phycoerythrin

The preferred DDR1 antibody is DDR1 Antibody (C-6): sc-374618.