T-bet/TBX21 Antibody (39D): sc-21763

T-bet Antibody (39D) is a mouse monoclonal IgG1 kappa light chain antibody that detects T-bet in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-T-bet antibody (39D) is available in a non-conjugated form, specifically designed for researchers seeking to study T-bet, a critical transcription factor that plays a pivotal role in the differentiation of T helper (Th) cells into Th1 and Th2 subsets. T-bet (39D) monoclonal antibody recognizes a Th1-specific transcription factor that regulates the expression of the Th1 cytokine, interferon-gamma (IFN-γ), which is essential for the immune response against intracellular pathogens. T-bet (39D) antibody helps researchers study how T-bet promotes the development of Th1 cells while inhibiting the differentiation of Th2 cells, maintaining a balance in the immune system. T-bet expression is tightly regulated by signals from the T cell receptor (TCR) and interleukin-12 (IL-12), which enhance levels during T cell activation. Originally isolated from nuclear extracts of resting and activated AE7 cells, T-bet is selectively expressed in Th1 cells, with expression significantly increasing upon stimulation. Understanding T-bet′s role in immune responses is crucial for developing therapeutic strategies for various diseases, including autoimmune disorders and infections.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-T-bet/TBX21 Antibody (39D) has 23 citations in a variety of scientific publications.

Primary antibodies like Anti-T-bet/TBX21 Antibody (39D) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

T-bet/TBX21 Antibody (39D) Specifications

Alternate Product Name: T-bet

Product Clone Name: 39D

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: T-bet

Epitope Species: mouse

Product Reactivity/Detection: T-bet

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 23 citations in various scientific publications

Available Conjugates/Forms for T-bet/TBX21 Antibody (39D): X: TransCruz Reagent

The preferred T-bet/TBX21 antibody is T-bet/TBX21 Antibody (4B10): sc-21749.