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- mouse monoclonal IgG1; 200 µg/ml
- raised against amino acids 317-327 of MMP-3 of human origin
- recommended for detection of MMP-3 of human origin by WB, IP, IF and IHC(P)
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Ordering InformationProduct Citations
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
MMP3 |
4314 |
11q22.2 |
NM_002422 |
P08254
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185250 |
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MMP-3 Background Information
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, -2 and -3 respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.
| MMP-3 (1B4) Product Citations |
See how others have used MMP-3 (1B4): sc-21732 antibody and or MMP-3 (1B4) antibody conjugates.
5 total citations Loading citations.
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MMP-3 (1B4)
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MMP-3 (1B4): sc-21732. Immunofluorescence staining of methanol-fixed Y-79 cells showing membrane staining.
MMP-3 (1B4): sc-21732. Western blot analysis of human recombinant MMP-3.
MMP-3 (1B4): sc-21732. Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate tissue showing cytoplasmic staining of glandular cells (low and high magnification). Kindly provided by The Swedish Human Protein Atlas (HPA) program.
MMP-3 (1B4): sc-21732. Western blot analysis of MMP-3 expression in HT-1080 (A), ECV 304 (B), HUV-EC-C (C), WI 38 (D), BJ (E) and CCD-1064SK (F) whole cell lysates.
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