ZAG Background Information ZAG (Zn-a2-glycoprotein, also designated Zn-a2-gp) is a soluble, secreted protein found in serum and other body fluids (such as cerebrospinal fluid, blood plasma, urine and sweat). ZAG has a tendency to precipitate with zinc salts, has electrophoretic mobility in the region of the two globulins, and has 18% carbohydrate content. A member of the immunoglobulin superfamily, ZAG has a high degree of sequence similarity to class-I major histocompatibility complex (MHC) antigens. The ZAG structure includes a large groove analogous to class I MHC peptide binding grooves. The crystal structure of ZAG resembles a class I MHC heavy chain but does not bind the class I light chain b-2-Microglobulin, unlike other MHC related proteins. ZAG stimulates lipid degradation in adipocytes and its overexpression causes the extensive fat losses associated with some advanced cancers.
ZAG (6G2)
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ZAG (6G2): sc-21721. Western blot analysis of ZAG expression in human peripheral blood cell lysate.
ZAG (6G2): sc-21721. Western blot analysis of ZAG expression in non-transfected: sc-117752 (A) and human ZAG transfected: sc-114991 (B) 293T whole cell lysates.
