recommended for detection of Substance P and neurokinins A and B of multiple species by IF and IHC(P); non-cross reactive with [Leu] enkephalin, [Met] enkephalin, somatostatin, or β-endorphin
Substance P Background Information Substance P (also designated NK-1) is an active peptide, known as a Tachykinin, that affects diverse functions, including blood pressure regulation, peristalsis of the gut, salivation and the modulation of cellular immunity. Frag-ments of Substance P have differential binding capacities for Substance P receptors and have varying biological activities. For example, two amino- terminal fragments of Substance P are able to evoke an increase in GABA release. NK-1 receptor (NK-1R), also designated Substance P receptor, binds to Tachykinin peptides, including Substance P, Substance K and Neuromedin K. In response to Substance P binding, NK-1R signals IL-12 production.
Substance P (NC1/34HL) Product Citations
See how others have used Substance P (NC1/34HL): sc-21715 antibody and or Substance P (NC1/34HL) antibody conjugates.
