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- rabbit polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of Rac 1 of human origin
- recommended for detection of Rac 1 and, to a lesser extent, Rac 3 of mouse, rat and human origin by WB, IP, IF and ELISA; non cross-reactive with Rac 2; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-217 P
- agarose conjugate for IP studies, sc-217 AC, 500 µg/0.25 ml agarose
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Rac 1 Background Information
A large number of low molecular weight, GTP binding proteins of the Ras superfamily have been identified. These proteins regulate many fundamental processes in all eukaryotic cells such as growth, vesicle traffic and cytoskeletal organization. GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. Two proteins in this family, Rac 1 and Rac 2, are 92% identical and share GTP binding and GTP hydrolysis motifs with other members of the Ras superfamily. Rac 1 is expressed in a large number of different cell types. Rac 2 is primarily expressed only in myeloid cells and has been reported to be a regulatory component of the human neutrophil NADPH oxidase.
| Rac 1 (C-14) Product Citations |
See how others have used Rac 1 (C-14): sc-217 antibody and or Rac 1 (C-14) antibody conjugates.
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Rac 1 (C-14)
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Rac 1 (C-14): sc-217. Western blot analysis of human recombinant Rac 1.
Rac 1 (C-14): sc-217. Immunofluorescence staining of methanol-fixed rat embryo fibroblasts using fluorescein-labeled goat anti-rabbit IgG secondary antibody.
Rac 1 (C-14): sc-217. Western blot analysis of Rac 1 expression in non-transfected 293T: sc-117752 (A), mouse Rac 1 transfected 293T: sc-122932 (B) and A-431 (C) whole cell lysates. |
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