p-Stat2 (Tyr 690)-R Antibody: sc-21689-R

Stat2 Background Information
Membrane receptor signaling by IFNa induces activation of the receptor-associated cytoplasmic tyrosine kinases of the Jak family (1,2). Jak activates Stat2 via the associaton of Jak with the Src homology 2 (SH2) domain of Stat2 (2–4). This activation leads to the phosphorylation of Stat2 on tyrosine 690 (2–4). The phosphorylated Stat2 dimerizes with Stat1 at the SH2 domain and the heterodimer translocates to the nucleus via nuclear import receptors importin-a5 and RAN (1,2,4,5). The Stat1/Stat2 heterodimer associates with p48 (also known as ISGF3g), a member of a separate DNA-binding family, forming the IFN-stimulated-gene factor 3 (ISGF3) (5–7). The ISGF3 complex binds to DNA through direct interaction of STAT1 and p48 to the IFN-stimulated response element on the DNA, and activates transcription of the IFN-responsive genes (1,2,5,6). The STAT2 gene maps to human chromosome 12q13.13 and is widely expressed in many tissues (7). Stat2 is an 851 amino acid long protein with a short isoform missing amino acids 653-851 due to alternative splicing (7).