 |
p-IKK α/β (Ser 176) Antibody: sc-21661 |
| Datasheet |
|
- goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-21661-R
- raised against a short amino acid sequence containing phosphorylated Ser 176 of IKKα of mouse origin
- recommended for detection of Ser 176 phosphorylated IKKα and Ser 177 phosphorylated IKKβ of mouse, rat and human origin by WB, IP and IF; also reactive with additional species, including canine, bovine and porcine
- blocking peptide, sc-21661 P
|
|
| |
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
IKK α/β Background Information
The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylated on specific Serine residues, which results in targeted degradation of IkB. IkB kinase a (IKKa) interacts with IkB-a and specifically phosphorylates IkB-a on the sites that trigger its degradation, Serines 32 and 36. The functional IKK complex contains three subunits, designated IKKa, IKKb and IKKg (also designated NEMO); each appears to make essential contributions to IkB phosphorylation. NFkB inducing kinase (NIK) phosphorylates IKKa at Serine 176.
| p-IKK α/β (Ser 176) Product Citations |
See how others have used p-IKK α/β (Ser 176): sc-21661 antibody and or p-IKK α/β (Ser 176) antibody conjugates.
8 total citations Loading citations.
|
| |
|
|
|
p-IKK α/β (Ser 176)
Click on image to enlarge
|
|
p-IKKα/β (Ser 176)-R: sc-21661-R. Western blot analysis of IKKα/β phosphorylation in untreated (A), TNFα treated (B) and TNFα and lambda protein phosphatase treated (C) HeLa whole cell lysates.
|
|
Download
|
|
