Date published: 2026-7-20

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Endothelin Antibodies

Santa Cruz Biotechnology features a diverse variety of Endothelin Antibodies for investigating endothelins in physiological and pathological processes. Endothelin Antibodies are validated for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Endothelins are potent vasoconstrictor peptides that play a critical role in regulating vascular tone and blood pressure. Beyond vascular regulation, endothelins influence cell proliferation, inflammation, and fibrosis processes. Cardiovascular research particularly benefits from studying endothelin functions, as they are implicated in conditions like hypertension and heart failure. Endothelin signaling pathways present numerous opportunities for therapeutic intervention in cardiovascular medicine. Understanding endothelin mechanisms can lead to breakthroughs in treating various vascular disorders. Researchers exploring endothelin biology can advance their work using Santa Cruz Biotechnology monoclonal antibodies, contributing to discoveries that may improve cardiovascular health outcomes.

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Endothelin Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

Endothelin-1/EDN1/ET-1 Antibody (1C10)

sc-57116mouse IgG1 κ1-21 (h)ELISAh
1
(1)

Endothelin-2/EDN2/ET-2 Antibody (3B4-1C5)

sc-293248mouse IgG2b κFL (h)WB, IP, ELISAh
1
(2)

Endothelin-3/EDN3/ET-3 Antibody (5E8)

sc-81944mouse IgG1 κFL (h)WB, IP, ELISAh

new

(2)

pan ET Antibody (3G10)

sc-57396rat IgG2b(h)IFh

new

(1)

Endothelin siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Endothelin-1/EDN1/ET-1 siRNA (h)

sc-45394hGene SilencingN/A
5
(0)

Endothelin-1/EDN1/ET-1 shRNA Plasmid (h)

sc-45394-SHhGene SilencingPuromycin
5
(0)

Endothelin-1/EDN1/ET-1 shRNA (h) Lentiviral Particles

sc-45394-VhGene SilencingPuromycin
5
(0)

Endothelin-1/EDN1/ET-1 siRNA (m)

sc-45395mGene SilencingN/A
2
(0)

Endothelin-1/EDN1/ET-1 shRNA Plasmid (m)

sc-45395-SHmGene SilencingPuromycin
2
(0)

Endothelin-1/EDN1/ET-1 shRNA (m) Lentiviral Particles

sc-45395-VmGene SilencingPuromycin
2
(0)

Endothelin-1/EDN1/ET-1 siRNA (r)

sc-270091rGene SilencingN/A0
(0)

Endothelin-1/EDN1/ET-1 shRNA Plasmid (r)

sc-270091-SHrGene SilencingPuromycin0
(0)

Endothelin-1/EDN1/ET-1 shRNA (r) Lentiviral Particles

sc-270091-VrGene SilencingPuromycin0
(0)

Endothelin-2/EDN2/ET-2 siRNA (h)

sc-45396hGene SilencingN/A0
(0)

Endothelin-2/EDN2/ET-2 shRNA Plasmid (h)

sc-45396-SHhGene SilencingPuromycin0
(0)

Endothelin-2/EDN2/ET-2 shRNA (h) Lentiviral Particles

sc-45396-VhGene SilencingPuromycin0
(0)

Endothelin-2/EDN2/ET-2 siRNA (m)

sc-144951mGene SilencingN/A0
(0)

Endothelin-2/EDN2/ET-2 shRNA Plasmid (m)

sc-144951-SHmGene SilencingPuromycin0
(0)

Endothelin-2/EDN2/ET-2 shRNA (m) Lentiviral Particles

sc-144951-VmGene SilencingPuromycin0
(0)

Endothelin-3/EDN3/ET-3 siRNA (h)

sc-45397hGene SilencingN/A0
(0)

Endothelin-3/EDN3/ET-3 shRNA Plasmid (h)

sc-45397-SHhGene SilencingPuromycin0
(0)

Endothelin-3/EDN3/ET-3 shRNA (h) Lentiviral Particles

sc-45397-VhGene SilencingPuromycin0
(0)

Endothelin-3/EDN3/ET-3 siRNA (m)

sc-45398mGene SilencingN/A0
(0)

Endothelin-3/EDN3/ET-3 shRNA Plasmid (m)

sc-45398-SHmGene SilencingPuromycin0
(0)

Endothelin-3/EDN3/ET-3 shRNA (m) Lentiviral Particles

sc-45398-VmGene SilencingPuromycin0
(0)

Endothelin CRISPR Knockout (KO) and HDR Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

Endothelin-1/EDN1/ET-1 CRISPR/Cas9 KO Plasmid (h)

sc-400564Gene Knockouth0
(0)

Endothelin-1/EDN1/ET-1 HDR Plasmid (h)

sc-400564-HDRHomology Directed Repairh0
(0)

Endothelin CRISPR Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

Endothelin-1/EDN1/ET-1 Double Nickase Plasmid (h)

sc-400564-NICGene Knockouth0
(0)

Endothelin-1/EDN1/ET-1 Double Nickase Plasmid (h2)

sc-400564-NIC-2Gene Knockouth0
(0)

Endothelin-2/EDN2/ET-2 Double Nickase Plasmid (h)

sc-403871-NICGene Knockouth0
(0)

Endothelin-2/EDN2/ET-2 Double Nickase Plasmid (h2)

sc-403871-NIC-2Gene Knockouth0
(0)

Endothelin-3/EDN3/ET-3 Double Nickase Plasmid (h)

sc-404436-NICGene Knockouth0
(0)

Endothelin-3/EDN3/ET-3 Double Nickase Plasmid (h2)

sc-404436-NIC-2Gene Knockouth0
(0)

Endothelin CRISPR Activation Plasmids and Lentiviral Particles

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

Endothelin-1/EDN1/ET-1 CRISPR Activation Plasmid (h)

sc-400564-ACTGene Activationh0
(0)

Endothelin-1/EDN1/ET-1 CRISPR Activation Plasmid (h2)

sc-400564-ACT-2Gene Activationh0
(0)

Endothelin-2/EDN2/ET-2 CRISPR Activation Plasmid (h)

sc-403871-ACTGene Activationh0
(0)

Endothelin-3/EDN3/ET-3 CRISPR Activation Plasmid (h)

sc-404436-ACTGene Activationh0
(0)