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Retrorsine (CAS 480-54-6)

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Synonym:β-Longilobine
Application:A cytotoxic pyrrolizidine alkaloid compound
CAS Number:480-54-6
Molecular Weight:351.39
Molecular Formula:C18H25NO6
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
Retrorsine sc-215805 100 mg $176
Retrorsine sc-215805A 500 mg $615
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Description
Retrorsine, a pyrrolizidine alkaloid, is a mutagenic, antimitotic, and cytotoxic compound. The toxicity of retrorsine relies on its bioactivation by cytochrome P450 enzymes (CYP). The toxicity of retrorsine has been shown to result from one of two compounds that are generated after CYP metabolism of retrorsine.
Technical Information
Appearance:White to Off White Solid
Physical State:Solid
Solubility:Soluble in Chloroform (25 mg/ mL) and ethanol
Storage:Store at room temperature
Melting Point:208 - 211 (°C) - lit.
Safety and Reference Information
Transport:UN 1544, Class 6.1, Packing group II
PubChem CID:5281743
SMILES:C\C=C1\C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Gordon, G.J., et al. 2000. Exp. Mol. Pathol. 69: 17-26. PMID: 10891289
2. Wang, Y.P., et al. 2005. Int J Environ Res Public Health. 2: 74-79. PMID: 16705803
3. Dai, J., et al. 2010. Chem. Biol. Interact. 183: 49-56. PMID: 19818743
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