epitope mapping at the C-terminus of MRTF-A of human origin
recommended for detection of MRTF-A of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
MRTF-A Background Information Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF regulates the transient response of several muscle genes in response to growth factors and recruits accessory myogenic factors to activate these muscle genes. SRF is required for the formation of vertebrate mesoderm leading to the origin of the cardiovascular system. Myocardin, in association with SRF in cardiac muscle cells, activates cardiac muscle promoters. Myocardin-related transcription factor A (MRTF-A), also known as MKL1, interacts with SRF and stimulates its transcriptional activity.
MRTF-A (C-19) Product Citations
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MRTF-A (C-19)
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MRTF-A (C-19): sc-21558. Western blot analysis of MRTF-A expression in NIH/3T3 nuclear extract.
