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Necrostatin-5: sc-215545

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  • C19H17N3O2S2, MW: 383.49, CAS: 337349-54-9
  • available in 5 mg (sc-215545) and 25 mg (sc-215545A) sizes
  • An inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase. Necroptosis is defined as alternative active cell death pathway: Death-Domain Receptor (DRs, e.g. Fas/TNFR) mediated and caspase-inhibitor insensitive with specific morphology (nuclear condensation, organelle swelling, loss of plasma membrane integrity). The necrostatins have been discovered to inhibit this pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved: T-loop dependent inhibition by necrostatin-1 partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5, since necrostatin-5 is a potent inhibitor of immunnoprecipitated RIP1, but does not inhibit recombinant RIP1.
  • Soluble in DMSO: >10 mg/mL
  • white solid
  • 1. Degterev, A., et al. 2008. Nat. Chem. Biol. 4: 313-321.
    2. Wang, K., et al., 2007. Bioorg. Med. Chem. Lett. 17: 1455-1465.
  • For Research Use Only
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
Necrostatin-5 sc-215545 5 mg $58
Necrostatin-5 sc-215545A 25 mg $228
Necrostatin-5 Data
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sc-215545
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