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Necrostatin-5 (CAS 337349-54-9)

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Synonym:2 [[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2, 3- d]pyrimidin-2-yl]thio]-acetonitrile; Nec-5
Application:An inhibitor of necroptosis by indirect inhibition of RIP1 kinase
CAS Number:337349-54-9
Molecular Weight:383.49
Molecular Formula:C19H17N3O2S2
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Necrostatin-5 sc-215545 5 mg $60
Necrostatin-5 sc-215545A 25 mg $250
Necrostatin-5 is an inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase. Necroptosis is defined as alternative active cell death pathway: Death-Domain Receptor (DRs, e.g. Fas/TNFR) mediated and caspase-inhibitor insensitive with specific morphology (nuclear condensation, organelle swelling, loss of plasma membrane integrity). The necrostatins have been discovered to inhibit this pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved: T-loop dependent inhibition by necrostatin-1 partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5, since necrostatin-5 is a potent inhibitor of immunnoprecipitated RIP1, but does not inhibit recombinant RIP1.
Technical Information
Physical State:Solid
Solubility:Soluble in DMSO: >10 mg/mL
Storage:Store at 4° C
Safety and Reference Information
PubChem CID:1913406
MDL Number:MFCD01448275
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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1. Degterev, A., et al. 2008. Nat. Chem. Biol. 4: 313-321. PMID: 18408713
2. Wang, K., et al. 2007. Bioorg. Med. Chem. Lett. 17: 1455-1465. PMID: 17270434
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