SW480 nuclear extract: sc-2155

SW480 nuclear extract, derived from the SW480 cell line originating from human colorectal adenocarcinoma, is pivotal in studying the nuclear processes related to cancer cell biology, particularly in colorectal cancer. This extract is enriched with transcription factors and other nuclear proteins involved in cell cycle regulation, apoptosis, and cellular differentiation. Researchers employ SW480 nuclear extract primarily to investigate transcriptional regulation mechanisms by conducting electrophoretic mobility shift assays (EMSA) to monitor DNA-protein interactions, and chromatin immunoprecipitation (ChIP) assays to explain the role of specific transcription factors and histone modifications in gene expression. Additionally, these extracts are used in co-immunoprecipitation experiments to explore protein-protein interactions within the nucleus, providing insights into the signaling pathways that are critical for tumor growth and progression. The use of SW480 nuclear extract helps researchers to understand the fundamental aspects of cancer cell genetics and molecular biology. Ensuring the authenticity and provenance of the SW480 cell line is crucial to maintain the validity and reliability of the experimental outcomes in cancer research.

SW480 nuclear extract References:

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