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DNA pol λ (V-17) Antibody: sc-2
1531 |
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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of DNA pol λ of human origin
- recommended for detection of DNA pol λ of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
- blocking peptide, sc-21531 P
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DNA pol λ Background Information
DNA polymerase lambda (pol ¬), also designated DNA polymerase ˚ or Pol ∫2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol ¬ is a member of the DNA polymerase type-X family. Pol ¬ extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol ¬ may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol ¬ and thus influences the ability of pol ¬ to synthesize DNA. |
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DNA pol λ (V-17)
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DNA pol λ (V-17): sc-21531. Western blot analysis of DNA pol λ expression in MCF7 (A), A549 (B), Hep G2 (C) and F9 (D) whole cell lysates. DNA pol (V-17): sc-21531. Western blot analysis of DNA pol expression in A549 (A), MCF7 (B) and HeLa (C) whole cell lysates and A549 (D) and MCF7 (E) nuclear extracts. |
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