ODC (N-15) Antibody: sc-21515

ODC Background Information
Ornithine decarboxylase (ODC) is an enzyme that performs the first step in polyamine biosynthesis by converting ornithine to putrescine and CO2. ODC plays an important role in diverse biological processes, including cell growth, differentiation, transformation and apoptosis. The Sp1, c-Myc and c-Fos genes function as transactivators and ZBP-89 as a transrepressor of the ODC promoter. Overexpression of ODC gene plays important roles in cell proliferation and the development of cancer. High levels of protein binding in the ODC promoter are implicated to the elevated constitutive expression of this gene. Elevated polyamine levels lead to downregulation of ODC activity by enhancing the translation of antizyme mRNA, resulting in subsequent binding of antizyme to ODC monomers to target ODC for proteolysis by the 26S Proteosome. DFMO (DL-a-difluoromethylornithine) is an irreversible inhibitor of ODC, which can induce apoptosis and inhibits cell growth. ODC is also associated with angiogenesis, and ODC-overexpressing cells exhibit suppressed expression of Type XVIII Collagen and endostatin, suggesting that overexpression of ODC facilitates endothelial proliferation by suppressing endostatin expression. The ODC gene maps to human chromosme 2p25.