MOLT-4 nuclear extract: sc-2151

The MOLT-4 nuclear extract is derived from the MOLT-4 cell line, a human T lymphoblast-like cell line originally established from a patient with acute lymphoblastic leukemia. This nuclear extract is rich in transcription factors, signaling molecules, and other nuclear proteins that are critical for T-cell function and regulation. The extract is extensively used in research to study T-cell signaling pathways, particularly those involving calcium flux, activation of transcription factors like NF-AT, and the regulation of genes involved in cell cycle and apoptosis. One significant area of application has been the study of transcriptional responses to external stimuli that mimic conditions of T-cell activation and proliferation. This allows researchers to explore the mechanisms that underlie T-cell mediated immunity and how these cells respond at a genetic level to various signals. Furthermore, the use of MOLT-4 nuclear extracts has facilitated the analysis of chromatin structure and modifications, offering insights into how epigenetic changes can influence T-cell behavior. These extracts provide a valuable tool for understanding the complex regulatory networks within T cells, focusing entirely on cellular and molecular biology research.

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