Molecular structure of Dehydroergosterol, CAS Number: 516-85-8
Dehydroergosterol (CAS 516-85-8)
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Alternate Names:
Ergosta-5,7,9(11),22-tetraen-3β-ol
Application:
Dehydroergosterol is a fluorescent cholesterol analog useful as a probe in membrane research
CAS Number:
516-85-8
Purity:
~96%
Molecular Weight:
394.63
Molecular Formula:
C28H42O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dehydroergosterol (DHE) is a sterol obtained from ergosterol, the primary sterol present in fungi. It serves as a prevalent element within the cell membrane of numerous fungi and is utilized as a biomarker. Dehydroergosterol is thought to function by disturbing the fungal cell membrane, ultimately resulting in cell demise. Additionally, it has been discovered to impede the synthesis of ergosterol, a vital constituent of the fungal cell membrane.
Dehydroergosterol (CAS 516-85-8) References
- Rapid transbilayer movement of the fluorescent sterol dehydroergosterol in lipid membranes. | John, K., et al. 2002. Biophys J. 83: 1525-34. PMID: 12202377
- Multiphoton laser-scanning microscopy and spatial analysis of dehydroergosterol distributions on plasma membrane of living cells. | McIntosh, AL., et al. 2007. Methods Mol Biol. 398: 85-105. PMID: 18214376
- The fluorescent cholesterol analog dehydroergosterol induces liquid-ordered domains in model membranes. | Garvik, O., et al. 2009. Chem Phys Lipids. 159: 114-8. PMID: 19477318
- Potential of ultraviolet wide-field imaging and multiphoton microscopy for analysis of dehydroergosterol in cellular membranes. | Wüstner, D., et al. 2011. Microsc Res Tech. 74: 92-108. PMID: 21181715
- Quantitative assessment of sterol traffic in living cells by dual labeling with dehydroergosterol and BODIPY-cholesterol. | Wüstner, D., et al. 2011. Chem Phys Lipids. 164: 221-35. PMID: 21291873
- Behavior of fluorescent cholesterol analogues dehydroergosterol and cholestatrienol in lipid bilayers: a molecular dynamics study. | Robalo, JR., et al. 2013. J Phys Chem B. 117: 5806-19. PMID: 23597397
- Dehydroergosterol as an analogue for cholesterol: why it mimics cholesterol so well-or does it? | Pourmousa, M., et al. 2014. J Phys Chem B. 118: 7345-57. PMID: 24893063
- Identification of a novel dehydroergosterol enhancing microglial anti-inflammatory activity in a dairy product fermented with Penicillium candidum. | Ano, Y., et al. 2015. PLoS One. 10: e0116598. PMID: 25760331
- Hybrid of dehydroergosterol and nitrogenous alternariol derivative from the fungus Pestalotiopsis uvicola. | Hou, GM., et al. 2018. Steroids. 138: 43-46. PMID: 30003909
- Examination of the association states of dehydroergosterol towards understanding the association structures of sterols in a membrane. | Kuroi, K., et al. 2019. Biochem Biophys Res Commun. 515: 228-233. PMID: 31146916
- A fluorescence study of dehydroergosterol in phosphatidylcholine bilayer vesicles. | Schroeder, F., et al. 1987. Biochemistry. 26: 2441-8. PMID: 3607026
- Depolarization of dehydroergosterol in phospholipid bilayers. | Chong, PL. and Thompson, TE. 1986. Biochim Biophys Acta. 863: 53-62. PMID: 3778912
- Asymmetric transbilayer distribution of sterol across plasma membranes determined by fluorescence quenching of dehydroergosterol. | Hale, JE. and Schroeder, F. 1982. Eur J Biochem. 122: 649-61. PMID: 7060596
- Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog. | Mukherjee, S., et al. 1998. Biophys J. 75: 1915-25. PMID: 9746532
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dehydroergosterol, 5 mg | sc-214967 | 5 mg | $136.00 | |||
Dehydroergosterol, 50 mg | sc-214967A | 50 mg | $610.00 |