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D-Fructose 1,6-bisphosphate trisodium salt (CAS 38099-82-0)

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Alternate Names:
D(+)Fructofuranose 1,6-diphosphate trisodium salt; Harden-Young ester; Hexose diphosphate trisodium salt
Application:
D-Fructose 1,6-bisphosphate trisodium salt is may be used as an allosteric activator of enzymes such as pyruvate kinase and NAD+-dependent L-(+)-lactate dehydrogenase
CAS Number:
38099-82-0
Purity:
≥98%
Molecular Weight:
406.06
Molecular Formula:
C6H11Na3O12P2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D-Fructose 1,6-bisphosphate trisodium salt is a critical intermediate in the glycolytic pathway and is extensively used in research focused on cellular metabolism. As a key molecule in both the glycolysis and gluconeogenesis pathways, it is central to studies concerning the regulation of energy production within cells. Researchers employ this compound to investigate enzyme kinetics, particularly of aldolase and phosphofructokinase, which are enzymes directly involved in the conversion of D-Fructose 1,6-bisphosphate trisodium salt to other metabolites. This compound also plays a role in studies of metabolic flux and the dynamics of phosphate group transfer. Additionally, it is used as a standard in various analytical techniques to quantify enzyme activities or to study metabolic disorders that affect carbohydrate metabolism.


D-Fructose 1,6-bisphosphate trisodium salt (CAS 38099-82-0) References

  1. Exploring substrate binding and discrimination in fructose1, 6-bisphosphate and tagatose 1,6-bisphosphate aldolases.  |  Zgiby, SM., et al. 2000. Eur J Biochem. 267: 1858-68. PMID: 10712619
  2. A functional role for a flexible loop containing Glu182 in the class II fructose-1,6-bisphosphate aldolase from Escherichia coli.  |  Zgiby, S., et al. 2002. J Mol Biol. 315: 131-40. PMID: 11779234
  3. Fructose-1,6-bisphosphate does not preserve ATP in hypoxic-ischemic neonatal cerebrocortical slices.  |  Liu, J., et al. 2008. Brain Res. 1238: 230-8. PMID: 18725216
  4. The metal-binding sites of glycose phosphates.  |  Gilg, K., et al. 2009. Dalton Trans. 7934-45. PMID: 19771356
  5. Why in vivo may not equal in vitro - new effectors revealed by measurement of enzymatic activities under the same in vivo-like assay conditions.  |  García-Contreras, R., et al. 2012. FEBS J. 279: 4145-59. PMID: 22978366
  6. Mixed sugar-core-phosphate chelation of D-fructose 1,6-bisphosphate with the Re(V)O(tmen) metal fragment.  |  Steinborn, M., et al. 2013. Dalton Trans. 42: 5749-54. PMID: 23450251
  7. Fructose-1,6-bisphosphatase opposes renal carcinoma progression.  |  Li, B., et al. 2014. Nature. 513: 251-5. PMID: 25043030
  8. One-step preparation of zirconia coated silica microspheres and modification with d-fructose 1, 6-bisphosphate as stationary phase for hydrophilic interaction chromatography.  |  Song, Z., et al. 2017. J Chromatogr A. 1522: 30-37. PMID: 28958759
  9. Microwave-Assisted Hydrothermal Synthesis of Cellulose/Hydroxyapatite Nanocomposites.  |  Fu, LH., et al. 2016. Polymers (Basel). 8: PMID: 30974621
  10. A Feedback Circuitry between Polycomb Signaling and Fructose-1, 6-Bisphosphatase Enables Hepatic and Renal Tumorigenesis.  |  Liao, K., et al. 2020. Cancer Res. 80: 675-688. PMID: 31948940
  11. Role of mono- and divalent metal cations in the catalysis by yeast aldolase.  |  Kadonaga, JT. and Knowles, JR. 1983. Biochemistry. 22: 130-6. PMID: 6338913
  12. Fructose-1,6-bisphosphate reduces infarct volume after reversible middle cerebral artery occlusion in rats.  |  Kuluz, JW., et al. 1993. Stroke. 24: 1576-83. PMID: 8378964
  13. Identification of arginine 331 as an important active site residue in the class II fructose-1,6-bisphosphate aldolase of Escherichia coli.  |  Qamar, S., et al. 1996. Protein Sci. 5: 154-61. PMID: 8771208

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-Fructose 1,6-bisphosphate trisodium salt, 100 mg

sc-214805
100 mg
$30.00

D-Fructose 1,6-bisphosphate trisodium salt, 1 g

sc-214805A
1 g
$69.00

D-Fructose 1,6-bisphosphate trisodium salt, 5 g

sc-214805B
5 g
$144.00