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Citrate-dextrose solution (ACD) (CAS 8013-89-6) - chemical structure image
Molecular structure of Citrate-dextrose solution (ACD), CAS Number: 8013-89-6
Citrate-dextrose solution (ACD) (CAS 8013-89-6) - chemical structure image
Molecular structure of Citrate-dextrose solution (ACD), CAS Number: 8013-89-6
Molecular structure of Citrate-dextrose solution (ACD), CAS Number: 8013-89-6

Citrate-dextrose solution (ACD) (CAS 8013-89-6)

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See product citations (9)

Alternate Names:
Acid citrate-dextrose; Anticoagulant citrate-dextrose
Application:
Citrate-dextrose solution (ACD) is a solution useful for anticoagulation of whole blood. Not to be used for diagnostic, clinical, or therapeutic use.
CAS Number:
8013-89-6
Molecular Weight:
372.28
Molecular Formula:
C12H20O13
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Description
Technical Information
Safety Information
SDS & Certificate of Analysis

Citrate-dextrose solution (ACD) is used for anticoagulation of whole blood and erythrocyte survival. It works by chelating the calcium ions required for coagulation, thus preventing blood clotting. Citrate-dextrose solution (ACD) is supplied as 2 x 25 ml of a 0.2 µm-filtered, high quality solution packaged in sterile glass bottles with a rubber top.


Citrate-dextrose solution (ACD) (CAS 8013-89-6) References

  1. Identification of lysophospholipid receptors in human platelets: the relation of two agonists, lysophosphatidic acid and sphingosine 1-phosphate.  |  Motohashi, K., et al. 2000. FEBS Lett. 468: 189-93. PMID: 10692584
  2. [Comparative study of adenosine and inosine as corrigents of ACD (Acid Citrate Dextrose) solution in preservation of human blood].  |  Popović, DA. and Aleksić, S. 1975. Bilt Hematol Transfuz. 3: 11-5. PMID: 1225322
  3. Idiopathic hyperlipemia and primary hypercholesteremic xanthomatosis. III. Effects of intravenously administered heparin on the plasma proteins and lipids.  |  LEVER, WF., et al. 1954. J Invest Dermatol. 22: 71-84; discussion, 84-7. PMID: 13118255
  4. A note on the determination of some alkali salts of organic acids by ion exchange.  |  BLAUG, SM. 1956. J Am Pharm Assoc Am Pharm Assoc. 45: 274-5. PMID: 13319108
  5. Variations in levels of transaminases and lactic dehydrogenase in bank blood.  |  CROWLEY, LV. 1962. Clin Chem. 8: 626-9. PMID: 14024039
  6. Pediatric convective hemofiltration: Normocarb replacement fluid and citrate anticoagulation.  |  Bunchman, TE., et al. 2003. Am J Kidney Dis. 42: 1248-52. PMID: 14655197
  7. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura.  |  HARRINGTON, WJ., et al. 1951. J Lab Clin Med. 38: 1-10. PMID: 14850832
  8. Nosocomial outbreak of Pantoea agglomerans bacteraemia associated with contaminated anticoagulant citrate dextrose solution: new name, old bug?  |  Boszczowski, I., et al. 2012. J Hosp Infect. 80: 255-8. PMID: 22245117
  9. Implications of anticoagulants and gender on cell counts and growth factor concentration in platelet-rich plasma and platelet-rich gel supernatants from rabbits.  |  González, JC., et al. 2016. Vet Comp Orthop Traumatol. 29: 115-24. PMID: 26786984
  10. Stent malapposition and the risk of stent thrombosis: mechanistic insights from an in vitro model.  |  Foin, N., et al. 2017. EuroIntervention. 13: e1096-e1098. PMID: 28781241
  11. Simultaneous contamination of transfusion blood with Enterobacter agglomerans and Pseudomonas fluorescens, supposedly from the pilot tubes.  |  Felsby, M., et al. 1973. J Med Microbiol. 6: 413-6. PMID: 4726336
  12. Changes in calcium distribution during therapeutic plasmapheresis.  |  Roberts, WH., et al. 1984. Arch Pathol Lab Med. 108: 881-3. PMID: 6548363
  13. Posttransfusion viability of feline erythrocytes stored in acid-citrate-dextrose solution.  |  Marion, RS. and Smith, JE. 1983. J Am Vet Med Assoc. 183: 1459-60. PMID: 6654726
  14. Platelet plasma membrane glycoproteins. Evidence for the presence of nonequivalent disulfide bonds using nonreduced-reduced two-dimensional gel electrophoresis.  |  Phillips, DR. and Agin, PP. 1977. J Biol Chem. 252: 2121-6. PMID: 845165

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Citrate-dextrose solution (ACD), 50 ml

sc-214744
50 ml
$26.00

Can I use your product for PRP procedures which is platelet rich plasma procedures ? Thanks 

Asked by: Y 1968
Thank you for your question . Santa Cruz Biotechnology products are not for PRP procedures .
Answered by: BlakeJ
Date published: 2024-03-28

Is it OK to use expired 5 %dextrose and 0.45 sodium chloride

Asked by: Anonymous
Thank you for your question. It would be helpful if you could call us directly at 800-457-3801, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Service
Date published: 2021-12-22

How long can this preserve blood for? 

Asked by: Kittie_f4n
Please contact Technical Service
Answered by: Tech Sales
Date published: 2021-09-12

How long does this product last until expiration? Does it have to be refrigerated ? 

Asked by: Damar
Thank you for your question. We recommend storing this product at +4 °C and warranty its viability for one year if kept under those conditions. Please contact our technical service team for the expiry date of the currently available batch.
Answered by: Tech Support Europe
Date published: 2021-10-04

Can ACD be used for complete picture for platelet?If it can be used ,what ratio is needed for blood and ACD?

Asked by: laurel1994
Thank you for your question. Unfortunately we do not have a protocol for this use, but 1:12 seems to be a standard ratio to start with. Here is a possible helpful paper: http://www.ncbi.nlm.nih.gov/pubmed/8823453
Answered by: Tech Service
Date published: 2019-03-08

1. Is this ACD-A ? 2. Is this sterile ? 3. Can this be used in PRP treatments ?

Asked by: ORehman
Thank you for your question. sc-214744 is a standard ACD-A solution. It was prepared using aseptic techniques, but not tested for sterility. The purity is very high(>99%). It is not recommended for PRP treatments, this product is for research use only and not for human use or consumption.
Answered by: Tech Service
Date published: 2018-08-03

This products is safe to use in prp process in humans?

Asked by: SOL LARREA
Thank you for your question. No, this chemical is not safe to use in humans. The chemical we provide, Citrate-dextrose solution (ACD): sc-214744, is for research use only. It is not intended for diagnostic or therapeutic use.
Answered by: Technical Support
Date published: 2021-02-20

What percent of the solution is actually citrate or dextrose? How many grams of citrate, how many grams of dextrose are in solution?

Asked by: Jz28sail
Thank you for your question. The formulation for sc-214744, Citrate-dextrose solution (ACD) is standard ACD solution A containing 7.3 g of Citric Acid; 22 g of Sodium Citrate; and 24.5 g of Dextrose in 1000mL of Sterile Water. The solution is sterile-filtered and Endotoxin levels are less than 0.25 EU/ml. Each 50 milliliter bottle of sc-214744, Citrate-dextrose solution (ACD) contains 0.365 g of Citric Acid (anhydrous); 1.1 g of Sodium Citrate (dihydrate); and 1.225 g of Dextrose (monohydrate).
Answered by: Chemical Support 5
Date published: 2020-11-05
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Rated 5 out of 5 by from Great product! Great service!The service received when placing orders is fantastic! The product comes exactly as specified.
Date published: 2021-06-03
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Citrate-dextrose solution (ACD) is rated 5.0 out of 5 by 1.
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