 |
- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the C-terminus of APC5 of human origin
- recommended for detection of APC5 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-21417 P
|
|
| |
Ordering Information
Recommended Support Products:
(click button of application of choice)
| |
| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
ANAPC5 |
51433 |
12q24.31 |
NM_016237 |
Q9UJX4
|
606948 |
| Mouse |
Anapc5 |
59008 |
5 F |
|
Q8BTZ4
|
N/A |
| |
APC5 Background Information
The anaphase-promoting complex (APC) is composed of more than ten subunits, including APC1, APC2, APC4, APC5, APC7, APC8, APC10 and APC11. The APC acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to and activate the cyclin-ubiquitination activity of APCs. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC, thus preventing APC activation. APC5, also known as ANAPC5 or PDL-108, is a subunit of APC that mediates the interaction of APC with the transcription coactivators CBP and p300. |
|
|
APC5 (C-20)
Click on image to enlarge
|
|
APC5 (C-20): sc-21417. Western blot analysis of APC5 expression in untreated (A) and IL-4-treated Ramos (B) whole cell lysates and mouse brain tissue extract (C).
|
|
Download
|
|
