Date published: 2025-9-25
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Zinpyr-4 (CAS 502467-23-4) - chemical structure image
Molecular structure of Zinpyr-4, CAS Number: 502467-23-4
Zinpyr-4 (CAS 502467-23-4) - chemical structure image
Molecular structure of Zinpyr-4, CAS Number: 502467-23-4
Molecular structure of Zinpyr-4, CAS Number: 502467-23-4

Zinpyr-4 (CAS 502467-23-4)

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Alternate Names:
9-(o-Carboxyphenyl)-2-chloro-5-[2-{bis(2-pyridylmethyl)aminomethyl}-N-methylaniline]-6-hydroxy-3-xanthanone
Application:
Zinpyr-4 is a cell-permeable fluorescent probe
CAS Number:
502467-23-4
Molecular Weight:
683.15
Molecular Formula:
C40H31ClN4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

Zinpyr-4 is a fluorescent zinc biochemistry sensor. It is to detect and measure the concentration of zinc ions in biological samples. Zinpyr-4 is has high selectivity and sensitivity towards zinc ions, making it for studying zinc homeostasis and signaling in cells. This fluorescent probe exhibits a strong fluorescence enhancement upon binding to zinc ions, allowing for easy detection and quantification. Zinpyr-4 is stable and reliable, providing accurate and reproducible results in various experimental applications. Its use in biochemistry has contributed to a better understanding of the role of zinc in biological processes, and it continues to be important for studying metal ion homeostasis in living systems.


Zinpyr-4 (CAS 502467-23-4) References

  1. ZP4, an improved neuronal Zn2+ sensor of the Zinpyr family.  |  Burdette, SC., et al. 2003. J Am Chem Soc. 125: 1778-87. PMID: 12580603
  2. Method for identifying neuronal cells suffering zinc toxicity by use of a novel fluorescent sensor.  |  Frederickson, CJ., et al. 2004. J Neurosci Methods. 139: 79-89. PMID: 15351524
  3. Illuminating zinc in biological systems.  |  Lim, NC., et al. 2004. Chemistry. 11: 38-49. PMID: 15484196
  4. Measuring cell viability with membrane impermeable zinc fluorescent indicator.  |  Stork, CJ. and Li, YV. 2006. J Neurosci Methods. 155: 180-6. PMID: 16466804
  5. Determining zinc with commonly used calcium and zinc fluorescent indicators, a question on calcium signals.  |  Martin, JL., et al. 2006. Cell Calcium. 40: 393-402. PMID: 16764924
  6. Alterations of pulmonary zinc homeostasis and cytokine production following traumatic brain injury in rats.  |  Zhu, L., et al. 2007. Ann Clin Lab Sci. 37: 356-61. PMID: 18000293
  7. The zinc indicator FluoZin-3 is not perturbed significantly by physiological levels of calcium or magnesium.  |  Zhao, J., et al. 2008. Cell Calcium. 44: 422-6. PMID: 18353435
  8. Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta.  |  Adlard, PA., et al. 2008. Neuron. 59: 43-55. PMID: 18614028
  9. Erythropoietin inhibits the increase of intestinal labile zinc and the expression of inflammatory mediators after traumatic brain injury in rats.  |  Zhu, L., et al. 2009. J Trauma. 66: 730-6. PMID: 19276746
  10. The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion.  |  Solomou, A., et al. 2015. J Biol Chem. 290: 21432-42. PMID: 26178371
  11. Erythropoietin Inhibits the Increase of Pulmonary Labile Zinc and the Expression of Inflammatory Mediators Following Subarachnoid Hemorrhage in Rats.  |  Zhou, Y., et al. 2016. Neurocrit Care. 24: 472-80. PMID: 26627226
  12. Over-expression of Slc30a8/ZnT8 selectively in the mouse α cell impairs glucagon release and responses to hypoglycemia.  |  Solomou, A., et al. 2016. Nutr Metab (Lond). 13: 46. PMID: 27390586
  13. Alterations of Intestinal Labile Zinc and Cytokine Production Following Subarachnoid Hemorrhage in Rats.  |  Zhao, X., et al. 2016. Ann Clin Lab Sci. 46: 622-626. PMID: 27993875

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Product NameCatalog #UNITPriceQtyFAVORITES

Zinpyr-4, 1 mg

sc-213183
1 mg
$330.00

How do I store zinpyr-4 that has been solubilized in DMSO

Asked by: vg11
Thank you for contacting Santa Cruz Biotechnology. For assistance please contact technical service . Please call 800-457-3801 or email scbt@scbt.com.
Answered by: BlakeJ
Date published: 2025-05-09
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Rated 2 out of 5 by from This Indicator is NOT membrane permeablePlease fix the descrpition here are some quotes from Zinpyr-4 papers "Because synaptic vesicles remain intact throughout slice preparation,63 the inability of ZP4 to stain zinc-containing presynaptic terminals indicates that this probe cannot penetrate cellular membranes. In contrast to ZP4, membrane permeable probes such as TSQ and ZP1 stain these vesicles intensely. The impermeability of ZP4 may arise from either its charge at neutral pH, a dipole moment, or an inability to adopt a permeable lactone isomer.64 Both the healthy neurons and the cells damaged during seizures by the release of excitoxic Zn2+ are cut open by the microtome blade during tissue slicing, permitting ZP4 to enter the cells. Only the damaged neurons display intense fluorescence that indicates the presence of Zn2+ when stained" " In contrast, staining of live, cultured cells using similar procedures with ZP4 shows no evidence of intracellular labeling. These observations suggest that, unlike ZP1, ZP4 is impermeable to cell membranes." "Presumably, ZP4 fails to stain presynaptic terminals with zinc-filled vesicles in the frozen sections simply because it cannot penetrate them. Classical neurochemical procedures demonstrate that synaptic vesicles will remain intact and sequester their contents through tissue chopping, homogenization, and centrifugation, requiring harsh osmotic shock to rupture them (Mui et al., 1994). Consistent with this interpretation is that the same lack of staining is observed, for example, with the membrane-impermeable zinc fluorescent probe Newport Green (the hydrophilic salt), and with the membrane-impermeant mixture of apo carbonic anhydrase and 4-(aminosulfonyl)-7-(ethanolamino)-2,1,3-benzoxadiazole (ABD-N), which is a ratiometric zinc probe (Suh et al., 1999; Thompson et al., 1998). Finally, because ZP1 (permeable) stains the synaptic terminals with zinc-filled vesicles, whereas ZP4 (impermeable) does not, it seems virtually certain that the membrane permeability required for probes to enter vesicles is controlling the staining of the neuropil."
Date published: 2021-01-28
Rated 5 out of 5 by from Use it routinely in our labUse it routinely in our lab, works well.
Date published: 2015-06-11
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Zinpyr-4 is rated 3.5 out of 5 by 2.
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