Molecular structure of Zinpyr-1, CAS Number: 288574-78-7
Zinpyr-1 (CAS 288574-78-7)
See product citations (50)
Alternate Names:
Zinpyr-1 is also known as ZP-1.
Application:
Zinpyr-1 is a cell-permeable fluorescent probe that is selective for Zinc with a fluorescence Emmax = 527 nm.
CAS Number:
288574-78-7
Purity:
≥95%
Molecular Weight:
823.72
Molecular Formula:
C46H36Cl2N6O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Zinpyr-1 is a cell-permeable fluorescent probe that is selective for Zinc. It induces positive fluorescence upon metal ion complexation. The fluorescence maximum wavelength is Em. λ = 527 nm. Zinpyr-1 experiences a shift in excitation from 515 to 507 nm, with increasing zinc concentrations using an emission filter over 513 - 558 nm. It mainly stains the Golgi or a Golgi-associated vesicle and can also act as a PET sensor.
Zinpyr-1 (CAS 288574-78-7) References
- Evidence that synaptically-released zinc contributes to neuronal injury after traumatic brain injury. | Suh, SW., et al. 2000. Brain Res. 852: 268-73. PMID: 10678752
- Fluorescent sensors for Zn(2+) based on a fluorescein platform: synthesis, properties and intracellular distribution. | Burdette, SC., et al. 2001. J Am Chem Soc. 123: 7831-41. PMID: 11493056
- Lack of vesicular zinc in mossy fibers does not affect synaptic excitability of CA3 pyramidal cells in zinc transporter 3 knockout mice. | Lopantsev, V., et al. 2003. Neuroscience. 116: 237-48. PMID: 12535956
- Transition metal speciation in the cell: insights from the chemistry of metal ion receptors. | Finney, LA. and O'Halloran, TV. 2003. Science. 300: 931-6. PMID: 12738850
- Overview of mammalian zinc transporters. | Kambe, T., et al. 2004. Cell Mol Life Sci. 61: 49-68. PMID: 14704853
- Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study. | Devergnas, S., et al. 2004. Biochem Pharmacol. 68: 699-709. PMID: 15276077
- Single and three-color flow cytometry assay for intracellular zinc ion availability in human lymphocytes with Zinpyr-1 and double immunofluorescence: relationship with metallothioneins. | Malavolta, M., et al. 2006. Cytometry A. 69: 1043-53. PMID: 16998866
- The use of the zinc-fluorophore, Zinpyr-1, in the study of zinc homeostasis in Arabidopsis roots. | Sinclair, SA., et al. 2007. New Phytol. 174: 39-45. PMID: 17335495
- Manganese displacement from Zinpyr-1 allows zinc detection by fluorescence microscopy and magnetic resonance imaging. | You, Y., et al. 2010. Chem Commun (Camb). 46: 4139-41. PMID: 20454746
- Fluorescence quenching by photoinduced electron transfer in the Zn2+ sensor zinpyr-1: a computational investigation. | Kowalczyk, T., et al. 2010. J Phys Chem A. 114: 10427-34. PMID: 20809640
- Application of Zinpyr-1 for the investigation of zinc signals in Escherichia coli. | Haase, H., et al. 2013. Biometals. 26: 167-77. PMID: 23324851
- Intracellular zinc distribution in mitochondria, ER and the Golgi apparatus. | Lu, Q., et al. 2016. Int J Physiol Pathophysiol Pharmacol. 8: 35-43. PMID: 27186321
- Zinc Exacerbates Tau Pathology in a Tau Mouse Model. | Craven, KM., et al. 2018. J Alzheimers Dis. 64: 617-630. PMID: 29914030
- A Novel hAPP/htau Mouse Model of Alzheimer's Disease: Inclusion of APP With Tau Exacerbates Behavioral Deficits and Zinc Administration Heightens Tangle Pathology. | Lippi, SLP., et al. 2018. Front Aging Neurosci. 10: 382. PMID: 30524268
- Perfusion alters free zinc levels in the rodent brain. | Lippi, SLP., et al. 2019. J Neurosci Methods. 315: 14-16. PMID: 30599147
- Cytokinin-dependent regulatory module underlies the maintenance of zinc nutrition in rice. | Gao, S., et al. 2019. New Phytol. 224: 202-215. PMID: 31131881
- The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection. | Moskovskich, A., et al. 2019. Sci Rep. 9: 10471. PMID: 31320712
- Comparison of Free Zinc Levels Determined by Fluorescent Probes in THP1 Cells Using Microplate Reader and Flow Cytometer. | Alker, W. and Haase, H. 2021. Biol Trace Elem Res. 199: 2414-2419. PMID: 32865725
- Suppression of NtZIP4A/B Changes Zn and Cd Root-to-Shoot Translocation in a Zn/Cd Status-Dependent Manner. | Maślińska-Gromadka, K., et al. 2021. Int J Mol Sci. 22: PMID: 34069632
- Intracellular zinc during cell activation and zinc deficiency. | Rolles, B., et al. 2021. J Trace Elem Med Biol. 68: 126864. PMID: 34562730
- Multi-Modal Imaging to Assess the Follicular Delivery of Zinc Pyrithione. | Mangion, SE., et al. 2022. Pharmaceutics. 14: PMID: 35631659
- The role of zinc in selective neuronal death after transient global cerebral ischemia. | Koh, JY., et al. 1996. Science. 272: 1013-6. PMID: 8638123
- A New Cell-Permeable Fluorescent Probe for Zn2+ | Grant K. Walkup, et al. 2000. Journal Of The American Chemical Society. 122: 5644-5645.
Inhibitor of:
ZNF74.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Zinpyr-1, 5 mg | sc-213182 | 5 mg | $215.00 |