Date published: 2025-11-3

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Saccharin (CAS 81-07-2)

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Alternate Names:
1,2-Benzisothiazol-3(2H)-one 1,1-Dioxide
Application:
Saccharin is a non-nutritive sweetener
CAS Number:
81-07-2
Molecular Weight:
183.18
Molecular Formula:
C7H5NO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Saccharin is widely utilized in research focusing on taste perception and the biological mechanisms underlying sweet taste receptors. This artificial sweetener is studied for its ability to bind to and activate these receptors, which are located on the tongue′s taste buds, providing insights into the complex processes of taste signaling and perception. Research on Saccharin also explores its effects on the metabolic responses in the body, particularly how it influences insulin release and glucose metabolism despite not being a sugar. Additionally, Saccharin is used in environmental studies to trace the pathways and persistence of artificial sweeteners in water systems, helping to assess their impact on ecosystems. Investigations into the stability and degradation of Saccharin under various environmental conditions further contribute to understanding its long-term environmental effects.


Saccharin (CAS 81-07-2) References

  1. The health risks of saccharin revisited.  |  Ellwein, LB. and Cohen, SM. 1990. Crit Rev Toxicol. 20: 311-26. PMID: 2202324
  2. New saccharin derivatives as tyrosinase inhibitors.  |  Gençer, N., et al. 2012. Bioorg Med Chem. 20: 2811-21. PMID: 22494841
  3. Saccharin Taste Conditions Flavor Preference in Weanling Rats.  |  Ueji, K., et al. 2016. Chem Senses. 41: 135-41. PMID: 26514409
  4. The toxicological effects of saccharin in short-term genotoxicity assays.  |  Arnold, DL. and Boyes, BG. 1989. Mutat Res. 221: 69-132. PMID: 2671710
  5. Synthesis of Novel Saccharin Derivatives.  |  Rankin, GM. and Poulsen, SA. 2017. Molecules. 22: PMID: 28333118
  6. Heroin and saccharin demand and preference in rats.  |  Schwartz, LP., et al. 2017. Drug Alcohol Depend. 178: 87-93. PMID: 28645064
  7. Measurement of Saccharin and trans-Resveratrol Metabolites in Urine as Adherence Markers for Small Quantity Lipid-Based Nutrient Supplement Consumption.  |  Weinborn, V., et al. 2021. J Agric Food Chem. 69: 1107-1114. PMID: 33439009
  8. Dissecting operant alcohol self-administration using saccharin-fading procedure.  |  Calleja-Conde, J., et al. 2023. Neuropsychopharmacol Rep. 43: 12-22. PMID: 36727594
  9. The saccharin controversy.  |  Kalkhoff, RK. and Levin, ME. 1978. Diabetes Care. 1: 211-22. PMID: 400131
  10. Saccharin metabolism and tumorigenicity.  |  Sweatman, TW. and Renwick, AG. 1979. Science. 205: 1019-20. PMID: 472722
  11. Two-generation saccharin bioassays.  |  Arnold, DL. 1983. Environ Health Perspect. 50: 27-36. PMID: 6347682
  12. Saccharin: a toxicological and historical perspective.  |  Arnold, DL., et al. 1983. Toxicology. 27: 179-256. PMID: 6353664
  13. Saccharin's aversive taste in rats: evidence and implications.  |  Dess, NK. 1993. Neurosci Biobehav Rev. 17: 359-72. PMID: 8309647

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Saccharin, 100 mg

sc-212902
100 mg
$173.00

Saccharin, 1 g

sc-212902A
1 g
$235.00

Saccharin, 10 g

sc-212902B
10 g
$286.00