Date published: 2025-9-5

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Piperazine (CAS 110-85-0)

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Alternate Names:
1,4-Diazacyclohexane; Diethylenediamine
Application:
Piperazine is a buffer component in chromatography purifications and separations based on pH
CAS Number:
110-85-0
Molecular Weight:
86.14
Molecular Formula:
C4H10N2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Piperazine, a heterocyclic organic compound, is extensively utilized in scientific research due to its diverse range of applications. One of its primary mechanisms of action lies in its ability to act as a diamine building block in the synthesis of various organic molecules and pharmaceutical intermediates. In organic chemistry, piperazine serves as a key reagent in the preparation of complex molecules, including pharmaceuticals, agrochemicals, and materials science compounds. Its unique chemical structure, characterized by two nitrogen atoms separated by a methylene bridge, enables it to participate in a variety of chemical reactions, such as nucleophilic substitution, amidation, and cyclization reactions. Additionally, piperazine derivatives exhibit biological activity and have been extensively studied in medicinal chemistry research for their potential as agents. Researchers have investigated the pharmacological properties of piperazine-containing compounds, exploring their interactions with biological targets such as receptors, enzymes, and ion channels. Furthermore, piperazine and its derivatives have found applications in the development of antiviral, antibacterial, antifungal, and anticancer agents, highlighting their importance in drug discovery and development. Beyond medicinal chemistry, piperazine-based compounds are also utilized in the synthesis of organic polymers, catalysts, and functional materials. Overall, piperazine′s versatile chemical properties make it a valuable tool in various research fields, contributing to advancements in organic synthesis, drug discovery, and materials science.


Piperazine (CAS 110-85-0) References

  1. Enhanced pepsin digestion: a novel process for purifying antibody F(ab')(2) fragments in high yield from serum.  |  Jones, RG. and Landon, J. 2002. J Immunol Methods. 263: 57-74. PMID: 12009204
  2. Purification and characterization of an extracellular beta-lactamase produced by Acinetobacter calcoaceticus.  |  Blechschmidt, B., et al. 1992. J Gen Microbiol. 138: 1197-202. PMID: 1527494
  3. Piperazine compounds as drugs of abuse.  |  Arbo, MD., et al. 2012. Drug Alcohol Depend. 122: 174-85. PMID: 22071119
  4. Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents.  |  Shaquiquzzaman, M., et al. 2015. Eur J Med Chem. 102: 487-529. PMID: 26310894
  5. Piperazine derivatives for therapeutic use: a patent review (2010-present).  |  Rathi, AK., et al. 2016. Expert Opin Ther Pat. 26: 777-97. PMID: 27177234
  6. Piperazine derivatives as dangerous abused compounds.  |  Welz, A. and Koba, M. 2020. Acta Pharm. 70: 423-441. PMID: 32412428
  7. Piperazine: A Promising Scaffold with Analgesic and Anti-inflammatory Potential.  |  Jain, A., et al. 2021. Drug Res (Stuttg). 71: 62-72. PMID: 33336346
  8. Piperazine, a Key Substructure for Antidepressants: Its Role in Developments and Structure-Activity Relationships.  |  Kumar, RR., et al. 2021. ChemMedChem. 16: 1878-1901. PMID: 33751807
  9. Piperazine skeleton in the structural modification of natural products: a review.  |  Zhang, RH., et al. 2021. J Enzyme Inhib Med Chem. 36: 1165-1197. PMID: 34080510
  10. Applications of Isosteres of Piperazine in the Design of Biologically Active Compounds: Part 1.  |  Meanwell, NA. and Loiseleur, O. 2022. J Agric Food Chem. 70: 10942-10971. PMID: 35675050

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Piperazine, 5 g

sc-212561
5 g
$10.00

Piperazine, 100 g

sc-212561A
100 g
$27.00