splicing factor 1 (N-14) Antibody: sc-21157

splicing factor 1 Background Information
Mammalian splicing factor 1 (designated SF1, zinc finger protein 162, ZFM1, CW17R and mammalian branch point binding protein [mBBP]) specifically recognizes the seven-nucleotide branch point sequence located at 3’ splice sites and participates in the assembly of early spliceosomal complexes (1,2). Splicing factor 1 functions as a transcriptional repressor and may control both proliferation and expression of pro-inflammatory gene products in smooth muscle cells (3). In addition, cytokine-induced downregulation of splicing factor 1 expression may contribute to the pathogenesis of hyperproliferative inflammatory diseases (3). The structure of splicing factor 1 contains a nuclear transport domain, a metal binding motif, and glutamine- and proline-rich regions (4). Human splicing factor 1 also exists as several different isoforms, H1-isoform and Bo-isoform, produced by alternative splicing events (5). The human splicing factor 1 gene is located on chromosome 11 close to the gene encoding Menin, the gene responsible for multiple endocrine neoplasia-type 1 (MEN1) (5).