Fenofibric Acid (CAS 42017-89-0)
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Fenofibric acid functions as a peroxisome proliferator-activated receptor alpha (PPARα) agonist. It acts by binding to and activating PPARα, a nuclear receptor that regulates the expression of genes involved in lipid metabolism. Upon activation, PPARα forms a heterodimer with the retinoid X receptor (RXR) and binds to specific DNA sequences known as PPAR response elements (PPREs) in the promoter regions of target genes. This binding leads to the transcriptional activation of genes involved in fatty acid oxidation, lipoprotein metabolism, and glucose homeostasis. By modulating the expression of these genes, fenofibric acid ultimately influences lipid and lipoprotein metabolism, leading to changes in plasma lipid levels. Its mechanism of action involves the regulation of various enzymes and transport proteins involved in lipid metabolism, such as lipoprotein lipase, apolipoprotein A-I, and apolipoprotein C-III.
Fenofibric Acid (CAS 42017-89-0) References
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- Dilazep and fenofibric acid inhibit MCP-1 mRNA expression in glycoxidized LDL-stimulated human endothelial cells. | Sonoki, K., et al. 2003. Eur J Pharmacol. 475: 139-47. PMID: 12954370
- Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner. | Arakawa, R., et al. 2005. Arterioscler Thromb Vasc Biol. 25: 1193-7. PMID: 15790930
- Determination of fenofibric acid in human plasma by ultra performance liquid chromatography-electrospray ionization mass spectrometry: application to a bioequivalence study. | Bhavesh, D., et al. 2009. Biomed Chromatogr. 23: 922-8. PMID: 19353730
- Fenofibric acid: in combination therapy in the treatment of mixed dyslipidemia. | Yang, LP. and Keating, GM. 2009. Am J Cardiovasc Drugs. 9: 401-9. PMID: 19929038
- Efficacy and safety of fenofibric acid co-administered with low- or moderate-dose statin in patients with mixed dyslipidemia and type 2 diabetes mellitus: results of a pooled subgroup analysis from three randomized, controlled, double-blind trials. | Jones, PH., et al. 2010. Am J Cardiovasc Drugs. 10: 73-84. PMID: 20136164
- Fenofibric acid prevents retinal pigment epithelium disruption induced by interleukin-1β by suppressing AMP-activated protein kinase (AMPK) activation. | Villarroel, M., et al. 2011. Diabetologia. 54: 1543-53. PMID: 21369818
- Atorvastatin and fenofibric acid differentially affect the release of adipokines in the visceral and subcutaneous cultures of adipocytes that were obtained from patients with and without mixed dyslipidemia. | Łabuzek, K., et al. 2011. Pharmacol Rep. 63: 1124-36. PMID: 22180354
- Effect of magnesium carbonate on the solubility, dissolution and oral bioavailability of fenofibric acid powder as an alkalising solubilizer. | Kim, KS., et al. 2016. Arch Pharm Res. 39: 531-538. PMID: 26992922
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- The effect of fenofibric acid on the pharmacokinetics and pharmacodynamics of warfarin in rats. | Guo, C., et al. 2018. Xenobiotica. 48: 400-406. PMID: 28287050
- Determination of Fenofibric Acid in Rat Plasma and its Application to a Comparative Pharmacokinetic Study of JW322 and Fenofibrate. | Kim, TK. 2017. Drug Res (Stuttg). 67: 534-538. PMID: 28561239
- Functional and Structural Insights into Human PPARα/δ/γ Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate. | Honda, A., et al. 2022. Int J Mol Sci. 23: PMID: 35563117
- Novel Inhibitory Role of Fenofibric Acid by Targeting Cryptic Site on the RBD of SARS-CoV-2. | Huang, J., et al. 2023. Biomolecules. 13: PMID: 36830728
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fenofibric Acid, 10 mg | sc-211501 | 10 mg | $57.00 | |||
Fenofibric Acid, 100 mg | sc-211501A | 100 mg | $124.00 | |||
Fenofibric Acid, 1 g | sc-211501B | 1 g | $136.00 |