Dehydro Aripiprazole Hydrochloride (CAS 1008531-60-9)

Dehydro Aripiprazole Hydrochloride, a metabolite of Aripiprazole, exhibits selective dopamine D2-receptor antagonist properties with dopamine autoreceptor agonist activity. Primarily, this compound serves as a tool in the realm of biochemical research, particularly in studies focused on elucidating the mechanisms of action of atypical antipsychotics and their metabolic pathways. The introduction of the dehydro modification imbues the molecule with unique physicochemical properties, enabling researchers to dissect the intricacies of receptor binding affinity, specificity, and the downstream effects on neurotransmitter systems. By comparing the pharmacodynamics and pharmacokinetics of Dehydro Aripiprazole Hydrochloride with its progenitor molecule, scientists gain invaluable insights into the role of structural modifications in drug-receptor interactions, offering a scaffold for the rational design of novel compounds with optimized efficacy and reduced off-target effects. This investigative utility underscores its significance in the development and refinement of biochemical assays and models that simulate the complex interplay between psychoactive substances and brain chemistry.