Molecular structure of Bromperidol, CAS Number: 10457-90-6
Bromperidol (CAS 10457-90-6)
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Alternate Names:
4-[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone
Application:
Bromperidol is a D2DR (dopamine D2 receptor) antagonist
CAS Number:
10457-90-6
Molecular Weight:
420.32
Molecular Formula:
C21H23BrFNO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bromperidol is a bromine analog of Haloperidol hydrochloride (sc-203593) which functions as a D2DR (dopamine D2 receptor) antagonist. Studies suggest that cytochrome CYP3A4 catalyzes the dehydration of Bromperidol and N-dealkylation of Bromperidol. In addition, CYP3A4 can oxidize N-dealkylated Bromperidol back into Bromperidol. Alternately, Bromperidol antagonizes the Neuroendocrine DA receptors which regulate hypothalamic LH-RH release. Bromperidol is an inhibitor of SR-2A.
Bromperidol (CAS 10457-90-6) References
- Role of CYP3A in bromperidol metabolism in rat in vitro and in vivo. | Watanabe, M., et al. 1999. Xenobiotica. 29: 839-46. PMID: 10553724
- Involvement of CYP3A4 in the metabolism of bromperidol in vitro. | Sato, S., et al. 2000. Pharmacol Toxicol. 86: 145-8. PMID: 10752674
- CYP3A is responsible for N-dealkylation of haloperidol and bromperidol and oxidation of their reduced forms by human liver microsomes. | Tateishi, T., et al. 2000. Life Sci. 67: 2913-20. PMID: 11133003
- Relationship between Taq1 A dopamine D2 receptor (DRD2) polymorphism and prolactin response to bromperidol. | Mihara, K., et al. 2001. Am J Med Genet. 105: 271-4. PMID: 11353448
- Therapeutic effects of bromperidol on the five dimensions of schizophrenic symptoms. | Yasui-Furukori, N., et al. 2002. Prog Neuropsychopharmacol Biol Psychiatry. 26: 53-7. PMID: 11853119
- Poor reliability of therapeutic drug monitoring data for haloperidol and bromperidol using enzyme immunoassay. | Yasui-Furukori, N., et al. 2003. Ther Drug Monit. 25: 709-14. PMID: 14639057
- Simultaneous determination of haloperidol and bromperidol and their reduced metabolites by liquid-liquid extraction and automated column-switching high-performance liquid chromatography. | Yasui-Furukori, N., et al. 2004. J Chromatogr B Analyt Technol Biomed Life Sci. 805: 175-80. PMID: 15113555
- Establishment of new cloned enzyme donor immunoassays (CEDIA) for haloperidol and bromperidol. | Yasui-Furukori, N., et al. 2004. Ther Drug Monit. 26: 336-41. PMID: 15167638
- Bromperidol decanoate (depot) for schizophrenia. | Purgato, M. and Adams, CE. 2012. Cochrane Database Syst Rev. 11: CD001719. PMID: 23152208
- The pharmacokinetics of long-acting antipsychotic medications. | Spanarello, S. and La Ferla, T. 2014. Curr Clin Pharmacol. 9: 310-7. PMID: 23343447
- Maintenance Treatment With Long-Acting Injectable Antipsychotics for People With Nonaffective Psychoses: A Network Meta-Analysis. | Ostuzzi, G., et al. 2021. Am J Psychiatry. 178: 424-436. PMID: 33596679
- Neuroendocrine effects of bromperidol. | Bianchi, A., et al. 1978. Acta Psychiatr Belg. 78: 69-82. PMID: 417559
- [Teratogenicity study on bromperidol in rats]. | Imai, S., et al. 1984. J Toxicol Sci. 9 Suppl 1: 109-26. PMID: 6149319
- No interaction between desipramine and bromperidol. | Suzuki, A., et al. 1996. Prog Neuropsychopharmacol Biol Psychiatry. 20: 1265-71. PMID: 8938825
Inhibitor of:
D2DR, and SR-2A.Activator of:
Thomsen-Friedenreich.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bromperidol, 100 mg | sc-210966 | 100 mg | $331.00 |