ATP6E Antibody (FL-226): sc-20946

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ATP6E, also known as V-ATPase E, is a vacuolar-type H+-ATPase (V-ATPase). V-ATPase is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and an integral V0 domain, which is responsible for proton translocation, compose V-ATPase. Nine subunits (A-H) make up the V1 domain and five subunits (a, d, c, c' and c") make up the V0 domain. Like F-ATPase, V-ATPase most likely operates through a rotary mechanism. ATP6E controls acidification of the vacuolar system and provides the main proton-motive force.