epitope mapping at the C-terminus of KCNQ4 of rat origin
recommended for detection of KCNQ4 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
KCNQ4 Background Information Epilepsy affects about 0.5% of the world’s population and has a large genetic component. Epilepsy results from an electrical hyperexcitability in the central nervous system. Potassium channels are important regulators of electrical signaling, determining the firing properties and responsiveness of a variety of neurons. Benign familial neonatal convulsions (BFNC), an autosomal dominant epilepsy of infancy, has been shown to be caused by mutations in the KCNQ2 or the KCNQ3 potassium channel genes. KCNQ2 and KCNQ3 are voltage-gated potassium channel proteins with six putative transmembrane domains. Both proteins display a broad distribution within the brain, with expression patterns that largely overlap. Mutations of KCNQ4 affect the functions of sensory outer hair cells and lead to
KCNQ4 (G-14) Product Citations
See how others have used KCNQ4 (G-14): sc-20882 antibody and or KCNQ4 (G-14) antibody conjugates.
