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Rosuvastatin Calcium Salt (CAS 147098-20-2)

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Synonym:(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic Acid Calcium Salt
Application:A selective and competitive inhibitor of HMG-CoA reductase
CAS Number:147098-20-2
Molecular Weight:1001.14
Molecular Formula:C44H54F2N6O12S2•Ca
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Rosuvastatin Calcium Salt sc-208316 10 mg $126
Rosuvastatin Calcium Salt is a selective, competitive inhibitor of HMGCR (HMG-CoA reductase), that is also antilipemic.
Technical Information
Physical State:Solid
Solubility:Soluble in water (< 1 mg/ml at 25° C), chloroform, DMSO (100 mg/ml at 25° C), methanol, and ethanol (< 1 mg/ml at 25° C).
Storage:Store at -20° C
Melting Point:151-156° C
Refractive Index:n20D 1.60 (Predicted)
Optical Activity:α20/D +6.8°, c = 1 in methanol; α20/D -9.9°, c = 1 in chloroform; α20/D +14.8°, c = 1.012 in 50% MeOH
IC50:HMG-CoA reductase: IC50 = 2.1 nM (rat); HMGCRHMGCRHMGCR: IC50 = 3.1 nM (human); Liver microsomes: IC50 = 3.6 nM (rat); L6: IC50 = 65 nM (rat); Plasmodium falciparum: IC50 = 80 µM
Ki Data:HMGCRHMGCRHMGCR: Ki= 0.9 (human)
Safety and Reference Information
PubChem CID:6436658
MDL Number:MFCD04112702
SMILES:CC(C1=NC(=NC(=C1/C=C/[C@H](O)C[C@@H](O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(=O)(=O) C)C)C.CC(C1=NC(=NC(=C1/C=C/[C@H](O)C[C@@H](O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(= O)(=O)C)C)C.[Ca+2]
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997), Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005), Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006),
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