Pentamidine (CAS 100-33-4)

Pentamidine is a diamidine compound that has become an important subject in biochemical research due to its binding affinity with nucleic acids. It is particularly useful for studying the interaction between small molecules and DNA or RNA, which is for understanding the regulation of gene expression and the mechanism of action of nucleic acid-targeting agents. In the field of parasitology, it serves as a reference compound in the study of protozoan biology and the identification of potential targets for new antiparasitic agents. Researchers also use pentamidine to investigate the mitochondrial dysfunction since it can interact with mitochondrial DNA and affect its function. Additionally, its role in inducing alterations in the cellular polyamine metabolism is of interest in cell biology, as polyamines are critical for cell growth and differentiation. The study of pentamidine and its analogs helps in elucidating the pathways of chemical resistance, particularly in the context of pathogenic organisms that alter their uptake or efflux mechanisms.